FIGURE 2 from First-in-human Phase I Trial of TPST-1120, an Inhibitor of PPARα, as Monotherapy or in Combination with Nivolumab, in Patients with Advanced Solid Tumors

A, PR in a 54-year-old female with RCC who had disease progression on prior anti-PD-1 therapy. Prior treatment included ipilimumab + nivolumab (first line), cabozantinib (second line), and everolimus (third line) with no better than SD on any regimen. She achieved a PR (−54%) after 8 weeks of treatment with TPST-1120 + nivolumab that deepened to −62% and was durable for more than 1 year. Changes in pulmonary lesions are shown in CT chest scans taken during screening and on-treatment. SD, stable disease. B, PR in an 84-year-old male with heavily pretreated extrahepatic cholangiocarcinoma. He had an initial increase in tumor burden followed by serial shrinking tumor scans before achieving a nadir of −34% and an overall response of PR at scan 4. SLD: sum of longest diameters.