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April 17, 2024International Immunopharmacology90 citationsOpen Access

Icariin inhibits chondrocyte ferroptosis and alleviates osteoarthritis by enhancing the SLC7A11/GPX4 signaling

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JXJuan XiaoCLChenggen LuoALAnmao Li

Key Points

  • Icariin suppresses chondrocyte ferroptosis and alleviates osteoarthritis pathology by directly enhancing protective SLC7A11/GPX4 signaling pathways.
  • The natural flavonoid glycoside provides critical cellular defense against cartilage damage, leveraging potent anti-inflammatory and antioxidant properties.
  • Targeting the SLC7A11/GPX4 signaling axis highlights a promising therapeutic mechanism for osteoarthritis; preclinical model validation remains necessary.

Abstract

Chondrocyte ferroptosis plays a critical role in the pathogenesis of osteoarthritis (OA), regulated by the SLC7A11/GPX4 signaling pathway. Icariin (ICA), a flavonoid glycoside, exhibits strong anti-inflammatory and antioxidant activities. This study investigated whether ICA could modulate the SLC7A11/GPX4 signaling to inhibit chondrocyte ferroptosis and alleviate OA.

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Cite This Study

Xiao et al. (2024) studied this question.

synapsesocial.com/papers/68e6eabeb6db643587665b1ehttps://doi.org/10.1016/j.intimp.2024.112010
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