Preclinical investigation reveals icariin reduces chondrocyte ferroptosis in osteoarthritis, highlighting therapeutic potential through SLC7A11/GPX4 pathway activation.
Chondrocyte ferroptosis plays a critical role in the pathogenesis of osteoarthritis (OA), regulated by the SLC7A11/GPX4 signaling pathway. Icariin (ICA), a flavonoid glycoside, exhibits strong anti-inflammatory and antioxidant activities. This study investigated whether ICA could modulate the SLC7A11/GPX4 signaling to inhibit chondrocyte ferroptosis and alleviate OA.
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Xiao et al. (2024) studied this question.
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