Laboratory study demonstrates neutralization of Mpox virus in vaccinated individuals after 45 years, suggesting durable immunologic memory maintained by polyclonal B cell activation.
To evaluate whether antibodies specific for the vaccinia virus (VV) are still detectable after at least 45 years from immunization. To confirm that VV-specific antibodies are endowed with the capacity to neutralize Mpox virus (MPXV) in vitro. To test a possible role of polyclonal non-specific activation in the maintenance of immunologic memory.
No takes yet. Share an insight, caveat, or question.
Mariotti et al. (2024) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: