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April 17, 2024Hematology ReportsOpen Access

Post-Transplant Cyclophosphamide versus Anti-Thymocyte Globulin in Patients with Hematological Malignancies Treated with Allogeneic Hematopoietic Stem Cell Transplantation from Haploidentical and Matched Unrelated Donors: A Real-Life Experience

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Authors

BSBianca SerioUniversity of SalernoGSGabriella StortiAzienda Ospedaliera S.Giuseppe MoscatiMDMatteo D’AddonaCleveland Clinic

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Implication

Retrospective observational study finds lower relapse and mortality with cyclophosphamide in stem cell recipients, suggesting clinical benefit over anti-thymocyte globulin.

Key Points

  • Disease relapse rates decreased significantly with post-transplant cyclophosphamide compared to anti-thymocyte globulin in allogeneic transplant recipients.
  • All-cause mortality was 36% with post-transplant cyclophosphamide compared to 75% under anti-thymocyte globulin among adult transplant recipients.
  • Retrospective observational study supports post-transplant cyclophosphamide to curb relapse, highlighting the need to balance graft versus host disease prophylaxis.

Cite This Study

Serio et al. (2024) studied this question.

synapsesocial.com/papers/68e6ebd7b6db643587666c1fhttps://doi.org/10.3390/hematolrep16020023
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Defining the Intensity of Conditioning Regimens: Working Definitions2009 · 1,843 citations
  2. 2Post‐transplantation cyclophosphamide versus conventional graft‐versus‐host disease prophylaxis in mismatched unrelated donor haematopoietic cell transplantation2016 · 86 citations
  3. 3Early Cardiac Toxicity Associated With Post-Transplant Cyclophosphamide in Allogeneic Stem Cell Transplantation2021 · 145 citations
  4. 4On Modeling Human Leukocyte Antigen–Identical Sibling Match Probability for Allogeneic Hematopoietic Cell Transplantation: Estimating the Need for an Unrelated Donor Source2015 · 110 citations
  5. 5Durable engraftment of major histocompatibility complex–incompatible cells after nonmyeloablative conditioning with fludarabine, low-dose total body irradiation, and posttransplantation cyclophosphamide2001 · 343 citations