⌘+K

Pulse Explore Clubs Researchers Journals

Home Clubs Explore

April 16, 2024iScienceOpen Access

Contrasting consequences of podocyte insulin-like growth factor 1 receptor inhibition

Jenny Hurcombe Fern Barrington Micol Marchetti Virginie M S Betin Emily E Bowen Abigail C Lay Lan Ni Lusyan Dayalan Robert J P Pope Paul T Brinkkoetter Martin Holzenberger Gavin I Welsh Richard J. Coward

View Full Paper

Ask AI

Bookmark

Share

Abstract

Insulin signaling to the glomerular podocyte via the insulin receptor (IR) is critical for kidney function. In this study we show that near-complete knockout of the closely related insulin-like growth factor 1 receptor (IGF1R) in podocytes is detrimental, resulting in albuminuria

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Hurcombe et al. (2024) studied this question.

synapsesocial.com/papers/68e6ee11b6db643587668ce8 https://doi.org/10.1016/j.isci.2024.109749

View Full Paper

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1The insulin / IGF axis is critically important controlling gene transcription in the podocyte.2024
2The insulin / IGF axis is critically important controlling gene transcription in the podocyte2025
3The insulin / IGF axis is critically important controlling gene transcription in the podocyte2025
4Insulin‐like growth factor 1 knockdown attenuates high glucose‐induced podocyte injury by promoting the <scp>JAK2</scp>/<scp>STAT</scp> signalling‐mediated autophagy2024 · 4 citations
5Albumin inhibits the insulin-mediated ACE2 increase in cultured podocytespreclinical · 2014 · 23 citations