High PSMA expression is associated with immunosuppressive tumor microenvironment in clear cell renal cell carcinoma

Clear cell renal cell carcinoma (ccRCC) is a highly vascular tumor.Among surrogate markers that may reflect the neovasculature burden of ccRCC, prostate specific membrane antigen (PSMA) has emerged as a promising one, by virtue of its ability to be measured either immunohistochemically (IHC) and transcriptionally or on positron emission tomography (PET) imaging.1,2 While the relationship