FIGURE 4 from Proteasome Inhibition Reprograms Chromatin Landscape in Breast Cancer

DOCR-associated TF motifs involve chromatin dynamics and cell fate. A, Heat map showing the degree of enrichment for top TFs binding motifs identified as enriched in each DOCR category. Each row corresponds to a TF. Each column corresponds to the DOCR genomic category and the heat map is split into DOCR class, Left (GAIN) and Right (LOST). B, Relative mRNA expression of TFs enriched at DOCRs, showing RNA-seq read counts in control (CTL) and 24H treated cells. C, Volcano plot showing the degree of differential binding and the statistical significance of the difference for all TF motifs queried. TF motifs with significant differential binding are colored red (increase) and blue (decrease). D, Relative mRNA expression of TFs identified by TOBIAS, showing RNA-seq read counts in control (CTL) and 24H treated cells. E, Dot plot showing the degree of enrichment for gene lists enriched with genes closest to DOCRs split by category. Dot size represents the number of genes in each Gene Ontology (GO) biological processes.