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You have accessJournal of UrologyProstate Cancer: Localized: Ablative Therapy I (MP25)1 May 2024MP25-07 DIAGNOSTIC PERFORMANCE OF PI-FAB (PROSTATE IMAGING AFTER FOCAL ABLATION): VALIDATION OF THE SCORING SYSTEM FOR MULTIPARAMETRIC MRI PERFORMED AFTER ABLATIVE TECHNIQUES FOR PROSTATE CANCER Mariaconsiglia Ferriero, Luca Bertini, Riccardo Mastroianni, Gabriele Tuderti, Aldo Brassetti, Alfredo Maria Bove, Leonardo Misuraca, Simone D'Annunzio, Flavia Proietti, Umberto Anceschi, Salvatore Guaglianone, Costantino Leonardo, and Giuseppe Simone Mariaconsiglia FerrieroMariaconsiglia Ferriero , Luca BertiniLuca Bertini , Riccardo MastroianniRiccardo Mastroianni , Gabriele TudertiGabriele Tuderti , Aldo BrassettiAldo Brassetti , Alfredo Maria BoveAlfredo Maria Bove , Leonardo MisuracaLeonardo Misuraca , Simone D'AnnunzioSimone D'Annunzio , Flavia ProiettiFlavia Proietti , Umberto AnceschiUmberto Anceschi , Salvatore GuaglianoneSalvatore Guaglianone , Costantino LeonardoCostantino Leonardo , and Giuseppe SimoneGiuseppe Simone View All Author Informationhttps://doi.org/10.1097/01.JU.0001008692.26556.39.07AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: The PI-FAB (Prostate Imaging after Focal Ablation) score has been recently introduced to evaluate MRI perfomed after ablation of prostate cancer (PCa). We report the diagnostic performance of PI-FAB in a retrospective analysis from a single centre experience of ablative techniques for PCa. METHODS: From February 2021 to September 2023, 174 ablative treatments for PCa were performed. We selected cases who underwent a multiparametric MRI (mpMRI) at 12 month-follow up. All exams were reviewed by our radiologist with expertise in reading MRI, who was blinded to PI-RADS score, and a PI-FAB score was assigned to each case. Patients with suspicious MRI received a rebiopsy, while cases with PI-RADS score ≤ 3 were followed with PSA. Sensitivity, specificity, positive, negative predictive value, accuracy and concordance rate of the two scores were evaluated. Univariable and Multivariable regression analysis were applied to identity predictors of disease recurrence (DR). RESULTS: Fifty-eight patients treated with cryoablation for localized PCa underwent a 12-month mpMRI and a PI-RADS score≥3 was reported in 22 (37.9%) cases. Overall, 2-yr disease free survival probability after cryoablation was 77.3%. (Figure 1) Ten patients, with PI-RADS score≥4 received a rebiopsy and DR was confirmed in 7 cases. (Table 1) Three cases with radiologic evidence of DR (confirmed by PET/CT scan) were treated without biopsy confirmation. PI-FAB score was assigned in 43 cases (not always applicable). Sensitivity, specificity, positive, negative predictive value and accuracy were 83.3%, 91.3%, 71.4%, 95.4%, 89.6% and 75%, 80.6%, 60%, 89.3%, 79.1%, for PI-RADS and PI-FAB score, respectively. Concordance rate of the two scores is 85.7%, with kappa index of 0.68. At univariable regression analysis PI-RADS Score >3 (HR 23.4 CI 3.84-142.5, p=0.001) and PI-FAB=3 (HR 11.1 CI 2.25-54.94, p=0.003) were predictors of DR detection (p=0.02) while at multivariable analysis only PI-RADS score >3 was independent predictor of DR (HR 13.4 CI 1.53-118.3, p=0.019). CONCLUSIONS: Despite some limitations of applicability, PI-FAB score could be a useful tool to identify disease recurrence after ablative treatments. PI-RADS remains the most accurate score for recurrent PCa detection. Download PPT Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e406 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Mariaconsiglia Ferriero More articles by this author Luca Bertini More articles by this author Riccardo Mastroianni More articles by this author Gabriele Tuderti More articles by this author Aldo Brassetti More articles by this author Alfredo Maria Bove More articles by this author Leonardo Misuraca More articles by this author Simone D'Annunzio More articles by this author Flavia Proietti More articles by this author Umberto Anceschi More articles by this author Salvatore Guaglianone More articles by this author Costantino Leonardo More articles by this author Giuseppe Simone More articles by this author Expand All Advertisement PDF downloadLoading ...
Ferriero et al. (Mon,) studied this question.