Mp53-17 Association Between the Number of Dissected Lymph Nodes and Prognosis in Patients Undergoing Radical Cystectomy Following Neoadjuvant Chemotherapy

You have accessJournal of UrologyBladder Cancer: Invasive V (MP53)1 May 2024MP53-17 ASSOCIATION BETWEEN THE NUMBER OF DISSECTED LYMPH NODES AND PROGNOSIS IN PATIENTS UNDERGOING RADICAL CYSTECTOMY FOLLOWING NEOADJUVANT CHEMOTHERAPY Kosuke Tochigi, Jun Nagayama, Yuri Yuguchi, Kyosuke Hattori, Sai Hiroki, Yoshie Kanada, Hirotaka Matsui, and Shusuke Akamatsu Kosuke TochigiKosuke Tochigi , Jun NagayamaJun Nagayama , Yuri YuguchiYuri Yuguchi , Kyosuke HattoriKyosuke Hattori , Sai HirokiSai Hiroki , Yoshie KanadaYoshie Kanada , Hirotaka MatsuiHirotaka Matsui , and Shusuke AkamatsuShusuke Akamatsu View All Author Informationhttps://doi.org/10.1097/01.JU.0001008784.37684.bd.17AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Many studies have shown a good prognostic association with a large number of dissected lymph nodes (DLNs). However, most of these studies did not include patients who have received neoadjuvant chemotherapy (NAC). The purpose of this study was to verify relationship between overall survival (OS) and number of DLNs in patients with radical cystectomy (RC) following NAC for muscle-invasive bladder cancer (MIBC). METHODS: This retrospective study considered patients who were diagnosed with clinical ≧T2N0M0 MIBC and treated with RC at Nagoya University Hospital and affiliated hospitals from January 2004 to August 2020. The association between prognosis and number of DLNs was investigated. RESULTS: We retrospectively enrolled a total of 507 patients. The mean number of DLNs was 14. 243 patients (48%) received NAC. ≧15 DLNs correlated with better 5-year OS across all patients (68.2% vs. 56.2%, p<0.01). In patients who received NAC, there was no difference in overall survival according to the number of DLNs (66.7% vs. 69.4%, p=0.777). In patients who did not received NAC ≧15 DLNs was associated with significantly better OS (70.1% vs. 46.9%, p<0.01). A greater number of DLNs was not associated with better OS in NAC patients (HR 1.27, 95% CI 0.78-2.05, p=0.33) under multivariate analysis. CONCLUSIONS: No association between a large number of DLNs and prognosis was found in patients who underwent NAC. Conversely, a large number of DLNs is desirable for patients who have not received NAC. Download PPTDownload PPT Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e870 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Kosuke Tochigi More articles by this author Jun Nagayama More articles by this author Yuri Yuguchi More articles by this author Kyosuke Hattori More articles by this author Sai Hiroki More articles by this author Yoshie Kanada More articles by this author Hirotaka Matsui More articles by this author Shusuke Akamatsu More articles by this author Expand All Advertisement PDF downloadLoading ...