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April 15, 2024Open Access

Functions of the Bloom Syndrome Helicase N-terminal Intrinsically Disordered Region

Colleen Bereda Evan B. Dewey M. Nasr Jeff Sekelsky

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Abstract

Bloom Syndrome helicase (Blm) is a RecQ family helicase involved in DNA repair, cell-cycle progression, and development. Pathogenic variants in human

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Cite This Study

Bereda et al. (2024) studied this question.

synapsesocial.com/papers/68e6f15fb6db64358766bcbe https://doi.org/10.1101/2024.04.12.589165

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Roles of the Bloom's syndrome helicase in the maintenance of genome stabilityOriginal Research · 2005 · 79 citations
2The Bloom's syndrome helicase promotes the annealing of complementary single-stranded DNAOriginal Research · 2005 · 146 citations
3The Bloom's Syndrome Gene Product Is a 3′-5′ DNA HelicaseOriginal Research · 1997 · 382 citations
4BLM helicase facilitates telomere replication during leading strand synthesis of telomeresOriginal Research · 2015 · 172 citations
5BLM Aggregation-Prone Ability and Similarity to Intrinsically Disordered Proteins Indicate its Potential Role in Neurodegenerative Diseases2024