Pharmacogenetics of psoriasis: predictors of the efficacy of anticytokine biological therapy

Psoriasis is a common chronic immune-mediated inflammatory inflammatory skin disease. The systemic nature of the inflammatory process, as well as the association with other diseases (psoriatic arthritis, inflammatory bowel disease, cardiovascular disease, depression, metabolic syndrome) significantly worsen the patient's quality of life, increasing the mortality curve. Different groups of drugs are used in the treatment of psoriasis, but according to the latest scientific data, the most effective is genetically engineered biological therapy, which targets key cytokines of psoriasis immunopathogenesis. Although there are numerous and effective biologics therapy used for the treatment of psoriasis, primary and secondary non-responders are becoming increasingly common, and not all patients achieve remission in the long term, which has a negative impact on quality of life. Identification of genetic markers associated with response to therapy using pharmacogenetic studies is a high current issue, as this presents new opportunities for personalized medicine and will identify genetic markers for each drug group. The review analyzes the available data from pharmacogenetic studies that have identified genes and their polymorphisms associated with response to biologics therapy.