Mp35-14 the Impact of Tumor Location on Intravesical Recurrence in Patients With Upper Tract Urothelial Carcinoma After Radical Nephroureterectomy

You have accessJournal of UrologyBladder Cancer: Epidemiology & Evaluation II (MP35)1 May 2024MP35-14 THE IMPACT OF TUMOR LOCATION ON INTRAVESICAL RECURRENCE IN PATIENTS WITH UPPER TRACT UROTHELIAL CARCINOMA AFTER RADICAL NEPHROURETERECTOMY Chiwen Lo, Yao-Chou Tsai, and Po-An Chong Chiwen LoChiwen Lo , Yao-Chou TsaiYao-Chou Tsai , and Po-An ChongPo-An Chong View All Author Informationhttps://doi.org/10.1097/01.JU.0001009372.61513.54.14AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: The intravesical recurrence (IVR) is a common discussion on the treatment of upper urinary tract urothelial carcinoma (UTUC). Most studies showed that ureter tumor has higher risk of IVR but there was no studies answer that whether tumor in different location has influence on IVR. We conducted a retrospective multi-institution study to answer this question. METHODS: From the data of Taiwan UTUC Collaboration Group, there were 4160 patients identified. We only enrolled patients received RNU with tumor purely located in single anatomical position.Those with multifocality, CIS, history of prior/concomitant bladder urothelial carcinoma, prior UTUC received renal sparing surgery or contralateral UTUC were excluded. Student's t test was adapted for continuous variables. The Pearson's Chi-square test was adapted for categorical variables. The univariate analysis was performed with logistic regression. Potential confounders that significantly confound the correlation between variables and outcomes were adjusted with logistic regression models. RESULTS: From 2008 to 2018, there were 766 patients enrolled in our study. The tabkle 1 shoewd the result of comparative multivariable survival analysis. The location of tumor was not related to the risk of IVR. Female gender has less risk of IVR (OR: 0.517, 95% CI: 0.340∼0.772, p: <0.001). Patient with low grade tumor has higher risk of IVR (OR: 1.288, 95% CI: 1.032∼1.609, p: 0.025) and adjuvant chemotherapy was the only relieve factor of IVR (OR: 0.493, 95% CI: 0.275∼0.883, p=0.017). CONCLUSIONS: Tumor location was not the risk factor of IVR. Female was the protective factor of IVR after RNU. The relationships between tumor grade/ adjuvant chemotherapy and IVR need further study confirm the result. Source of Funding: No source of funding © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e587 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Chiwen Lo More articles by this author Yao-Chou Tsai More articles by this author Po-An Chong More articles by this author Expand All Advertisement PDF downloadLoading ...