Mp08-13 Trigonal Tumor Location Is Associated With a Higher Tumor Stage and Cancer Recurrence in Patients Undergoing Robot-Assisted Radical Cystectomy

You have accessJournal of UrologyBladder Cancer: Epidemiology & Evaluation I (MP08)1 May 2024MP08-13 TRIGONAL TUMOR LOCATION IS ASSOCIATED WITH A HIGHER TUMOR STAGE AND CANCER RECURRENCE IN PATIENTS UNDERGOING ROBOT-ASSISTED RADICAL CYSTECTOMY Jonathan Li, Abdul Wasay Mahmood, Ava Giangrasso, Zaineb Ahmed, Zhe Jing, Ahmed A. Hussein, Khurshid A. Guru, and Qiang Li Jonathan LiJonathan Li , Abdul Wasay MahmoodAbdul Wasay Mahmood , Ava GiangrassoAva Giangrasso , Zaineb AhmedZaineb Ahmed , Zhe JingZhe Jing , Ahmed A. HusseinAhmed A. Hussein , Khurshid A. GuruKhurshid A. Guru , and Qiang LiQiang Li View All Author Informationhttps://doi.org/10.1097/01.JU.0001008780.87855.57.13AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: The trigone/prostatic urethra (T/U) has a distinct embryonic origin and a different histology morphology than the bladder walls. We sought to determine the association between tumors in the T/U and the presence of variant histology, pathologic and oncologic outcomes in patients undergoing robot-assisted radical cystectomy (RARC). METHODS: Tumor location was classified into two groups: tumors in the bladder wall, or tumors in the T/U group (with or without the bladder walls involved). Univariable and multivariable Cox regression and Cox proportional hazards regression were used to determine if the involvement of T/U was associated with recurrence, cancer-specific survival, and overall survival. RESULTS: A total of 608 patients who underwent RARC were identified, 191 (31%) were in the T/U. Patients in the T/U group were more likely to have pT3/pT4 (57% vs 42%, p<0.01), positive surgical margins (21% vs 9%, p<0.01), and received salvage chemotherapy more frequently (16% vs 8%, p<0.01) compared to the other group. The rate of variant histology in the T/U group was not statistically different (55% vs 49%, respectively, p=0.19). On multivariable analysis, T/U location was independently associated with recurrence (HR 1.63, 95% CI 1.23 – 2.16, p<0.01) and cancer-specific survival (HR 1.50, 95% CI 1.04 – 2.16, p=0.02). However, the association between tumors in the T/U and overall survival was not statistically significant. CONCLUSIONS: Bladder cancer patients with tumors involved in the T/U have a higher risk of an advanced tumor stage, positive margin, cancer recurrence, and cancer-specific survival. Download PPT Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e120 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Jonathan Li More articles by this author Abdul Wasay Mahmood More articles by this author Ava Giangrasso More articles by this author Zaineb Ahmed More articles by this author Zhe Jing More articles by this author Ahmed A. Hussein More articles by this author Khurshid A. Guru More articles by this author Qiang Li More articles by this author Expand All Advertisement PDF downloadLoading ...