Pd29-08 Association of Area Deprivation Index and Race With Prostate Cancer-Specific Mortality Among Black and White Men in a Contemporary North American Population

You have accessJournal of UrologyProstate Cancer: Epidemiology & Natural History I (PD29)1 May 2024PD29-08 ASSOCIATION OF AREA DEPRIVATION INDEX AND RACE WITH PROSTATE CANCER-SPECIFIC MORTALITY AMONG BLACK AND WHITE MEN IN A CONTEMPORARY NORTH AMERICAN POPULATION Giuseppe O. Cirulli, Giuseppe Chiarelli, Marco Finati, Alex Stephens, Patrick Etta, Mohit Butaney, Davis Matthew, Shane Tinsley, Chase Morrison, Akshay Sood, Nicolò Buffi, Giovanni Lughezzani, Giuseppe Carrieri, Andrea Salonia, Alberto Briganti, Francesco Montorsi, Craig Rogers, and Firas Abdollah Giuseppe O. CirulliGiuseppe O. Cirulli , Giuseppe ChiarelliGiuseppe Chiarelli , Marco FinatiMarco Finati , Alex StephensAlex Stephens , Patrick EttaPatrick Etta , Mohit ButaneyMohit Butaney , Davis MatthewDavis Matthew , Shane TinsleyShane Tinsley , Chase MorrisonChase Morrison , Akshay SoodAkshay Sood , Nicolò BuffiNicolò Buffi , Giovanni LughezzaniGiovanni Lughezzani , Giuseppe CarrieriGiuseppe Carrieri , Andrea SaloniaAndrea Salonia , Alberto BrigantiAlberto Briganti , Francesco MontorsiFrancesco Montorsi , Craig RogersCraig Rogers , and Firas AbdollahFiras Abdollah View All Author Informationhttps://doi.org/10.1097/01.JU.0001008736.23117.7f.08AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Increasing evidence indicates poor socioeconomic status and geographic residency in underprivileged areas as potential contributors to disparities in cancer outcomes. For this reason, the measurement of area-level social and economic deprivation index (ADI) can be useful as a predictor of cancer outcomes. We aimed to examine the impact of ADI and race on Prostate Cancer-Specific Mortality (PCSM) among Non-Hispanic Black (NHB) and Non-Hispanic White (NHW) men in a contemporary North American population. METHODS: We included men who got diagnosed whit PCa within Henry Ford Health (HFH), between 1995 and 2019. ADI is a percentile rank of socio-economic disadvantage, calculated using indicators of income level and disparity, educational level, employment rate, home values and quality of life. These indicators were used to create a deprivation score and patients were categorized by race and for ADI quartiles (based on the available National ADI decile values). The highest quartile (Q4: 75-100) represented individuals with the most disadvantageous socio-economic status. The main outcome for our study was PCSM. Competing-risk cumulative incidence curves were used to depict PCSM, after stratifying patients into sub-cohorts based on race and ADI quartiles. MVA was used to examine the impact of ADI quartiles on PCSM after adjusting for all available confounders. RESULTS: A total of 13,039 patients were included. Of these, 4,402 (33.8%) were NHB men. Median (IQR) PSA at diagnosis was 6.0 (4.5, 9.5) ng/ml. In the 4th ADI quartile, there were more NHB patients (60.1%) than White patients (39.9%) (p<0.001). The median (IQR) follow-up time was 5.7 (2.3-10.3) years. At 10-year, PCSM in NHW vs NHB patients was statistically different in the 1st ADI quartile (5.2% vs 10.4%, p<0.001), but not in the 2nd, 3rd, and 4th ADI quartile groups (all p>0.05). On multivariable analysis, NHW and NHB patients in the 4th ADI quartile (most disadvantaged area) had a 1.27-fold (95% CI: 1.02-1.58; p=0.030) higher cancer-specific mortality compared to NHW and NHB patients in the 1st ADI quartile, but race was not an independent predictor of cancer-specific mortality (HR:1.05; 95% CI:0.89-1.23; p=0.564). CONCLUSIONS: Our study was the first to assess the differential impact of ADI as a predictor of PCSM based on race in a large contemporary North American cohort. Within the first quartile, NHB patients showed higher cancer-specific mortality compared to NHW patients. Race itself was not identified as an independent predictor of cancer-specific mortality. Source of Funding: Vattikuti foundation and Menon foundation © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e621 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Giuseppe O. Cirulli More articles by this author Giuseppe Chiarelli More articles by this author Marco Finati More articles by this author Alex Stephens More articles by this author Patrick Etta More articles by this author Mohit Butaney More articles by this author Davis Matthew More articles by this author Shane Tinsley More articles by this author Chase Morrison More articles by this author Akshay Sood More articles by this author Nicolò Buffi More articles by this author Giovanni Lughezzani More articles by this author Giuseppe Carrieri More articles by this author Andrea Salonia More articles by this author Alberto Briganti More articles by this author Francesco Montorsi More articles by this author Craig Rogers More articles by this author Firas Abdollah More articles by this author Expand All Advertisement PDF downloadLoading ...