Pd50-02 Differential Impact of Prostate-Specific Antigen Screening Pattern on Prostate Cancer-Mortality Among Non-Hispanic Black and Non-Hispanic White Men: A Large, Urban Health System Cohort Analysis

You have accessJournal of UrologyProstate Cancer: Detection & Screening V (PD50)1 May 2024PD50-02 DIFFERENTIAL IMPACT OF PROSTATE-SPECIFIC ANTIGEN SCREENING PATTERN ON PROSTATE CANCER-MORTALITY AMONG NON-HISPANIC BLACK AND NON-HISPANIC WHITE MEN: A LARGE, URBAN HEALTH SYSTEM COHORT ANALYSIS Giuseppe O. Cirulli, Davis Matthew, Alex Stephens, Giuseppe Chiarelli, Marco Finati, Nicholas Corsi, Eric Williams, Rafe Affas, Akshay Sood, Nicolò Buffi, Giovanni Lughezzani, Giuseppe Carrieri, Andrea Salonia, Alberto Briganti, Francesco Montorsi, Craig Rogers, and Firas Abdollah Giuseppe O. CirulliGiuseppe O. Cirulli , Davis MatthewDavis Matthew , Alex StephensAlex Stephens , Giuseppe ChiarelliGiuseppe Chiarelli , Marco FinatiMarco Finati , Nicholas CorsiNicholas Corsi , Eric WilliamsEric Williams , Rafe AffasRafe Affas , Akshay SoodAkshay Sood , Nicolò BuffiNicolò Buffi , Giovanni LughezzaniGiovanni Lughezzani , Giuseppe CarrieriGiuseppe Carrieri , Andrea SaloniaAndrea Salonia , Alberto BrigantiAlberto Briganti , Francesco MontorsiFrancesco Montorsi , Craig RogersCraig Rogers , and Firas AbdollahFiras Abdollah View All Author Informationhttps://doi.org/10.1097/01.JU.0001008620.35181.96.02AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Randomized studies assessing the effect of prostate-specific antigen (PSA) screening on mortality in Non-Hispanic Black men (NHB) are lacking. The aim of our study was to assess the association between PSA screening and survival among NHB men in comparison to Non-Hispanic White (NHW) men in a racially diverse real-world North American population. METHODS: The study cohort included 6,378 men who self-identified as NHB or NHW and were diagnosed with prostate cancer (PCa). They received PSA screening and subsequent PCa treatment and follow-up at our institution between the years 2000 and 2019. Patients were sorted based on PSA testing intensity for the 5 years prior to diagnosis, as follows: never, some (<1 test/year), and annual testing (1 test/year). The primary outcome was risk of prostate cancer-specific mortality (PCSM) among NHB and NHW. Competing-risk cumulative incidence curves estimated PCSM rates. Fine-Gray regression analyses examined the impact of PSA testing on PCSM. RESULTS: Median (IQR) age and PSA at diagnosis were 67 (60-73) years and 5.8 (4.4-9.6) ng/ml, respectively and 2,929 (45.9%) men were NHB. Annual PSA testing was more frequent in NHW (5.2%) than in NHB (3.2%) men (p<0.001). On cumulative incidence analysis, in the never, some, and annual PSA testing groups, the 10-year PCSM was respectively 12.3%, 5.8%, and 4.6% in NHW and 18.5%, 7.0%, 1.2% in NHB patients (both p<0.001). On multivariable analysis, a more intensive PSA testing strategy was associated with more favorable PCSM rates for NHB (HR: 0.38; 95% CI 0.22-0.64; p<0.001) as well as NHW men (HR: 0.56; 95% CI 0.34-0.93; p=0.025). CONCLUSIONS: Annual PSA testing was associated with a reduced risk of PCSM in both NHB and NHW men who were diagnosed with PCa. NHB men seemed to benefit from frequent PSA testing compared to their NHW counterparts. Download PPTDownload PPT Source of Funding: Vattikuti foundation and Menon foundation © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e1056 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Giuseppe O. Cirulli More articles by this author Davis Matthew More articles by this author Alex Stephens More articles by this author Giuseppe Chiarelli More articles by this author Marco Finati More articles by this author Nicholas Corsi More articles by this author Eric Williams More articles by this author Rafe Affas More articles by this author Akshay Sood More articles by this author Nicolò Buffi More articles by this author Giovanni Lughezzani More articles by this author Giuseppe Carrieri More articles by this author Andrea Salonia More articles by this author Alberto Briganti More articles by this author Francesco Montorsi More articles by this author Craig Rogers More articles by this author Firas Abdollah More articles by this author Expand All Advertisement PDF downloadLoading ...