Mp44-10 Risk Factors of Renal Cell Carcinoma Late Recurrence: Korcc Registry Analysis

You have accessJournal of UrologyKidney Cancer: Localized: Surgical Therapy III (MP44)1 May 2024MP44-10 RISK FACTORS OF RENAL CELL CARCINOMA LATE RECURRENCE: KORCC REGISTRY ANALYSIS Younsoo Chung, Seok-Soo Byun, Sung Kyu Hong, Sangchul Lee, Jung Kwon Kim, Cheol Kwak, Ja Hyeon Ku, Chang Wook Jeong, Ji Youl Lee, Sung Hoo Hong, Yong-June Kim, Eu Chang Hwang, Tae Gyun Kwon, Tae-Hwan Kim, Seok Ho Kang, Jinsoo Chung, Jun Hyeon Nam, Hae Seong Lee, Jeong Keun Song, and Jeong Won Park Younsoo ChungYounsoo Chung , Seok-Soo ByunSeok-Soo Byun , Sung Kyu HongSung Kyu Hong , Sangchul LeeSangchul Lee , Jung Kwon KimJung Kwon Kim , Cheol KwakCheol Kwak , Ja Hyeon KuJa Hyeon Ku , Chang Wook JeongChang Wook Jeong , Ji Youl LeeJi Youl Lee , Sung Hoo HongSung Hoo Hong , Yong-June KimYong-June Kim , Eu Chang HwangEu Chang Hwang , Tae Gyun KwonTae Gyun Kwon , Tae-Hwan KimTae-Hwan Kim , Seok Ho KangSeok Ho Kang , Jinsoo ChungJinsoo Chung , Jun Hyeon NamJun Hyeon Nam , Hae Seong LeeHae Seong Lee , Jeong Keun SongJeong Keun Song , and Jeong Won ParkJeong Won Park View All Author Informationhttps://doi.org/10.1097/01.JU.0001009508.69111.d0.10AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: The objective of this research was to investigate the risk factors associated with late recurrence in patients with renal cell carcinoma (RCC) using data from the Korea Renal Cell Carcinoma (KORCC) registry. METHODS: In this retrospective study, we compared recurrences within three years of nephrectomy versus recurrences after three years patients. The logistic regression analysis was performed to evaluate risk factors for late recurrence. Kaplan-Meier curves were utilized to evaluate survival, and cox-regression analysis was performed to figure out the risk factor hazard ratio compared to the non-recurrence group. RESULTS: The late recurrence group had a considerably younger baseline age than the early recurrence group. Late recurrence group had lower pT stage, low portion of papillary type, and lower incidence of sarcomatoid differentiation. However, multiple logistic regression analysis showed only the absence of sarcomatoid differentiation as the risk factor. The Kaplan-Meier analysis showed that the late recurrence group had considerably higher rates of overall survival and cancer-specific survival. A cox-regression analysis comparing overall survival between the non-recurrence group and the late-recurrence group indicated higher preoperative Crp, higher pT stage, the absence of papillary type, the presence of necrosis, and the presence of capsule invasion as significant risk factors. CONCLUSIONS: Patients with greater preoperative C-reactive protein levels, higher pT stage, and evidence of necrosis or capsule invasion should be continuously followed because of the increased risk of late recurrence. Patients with papillary type or sarcomatoid differentiation are more likely to recur earlier and should be followed often for the first three years after nephrectomy. Source of Funding: No funding © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e734 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Younsoo Chung More articles by this author Seok-Soo Byun More articles by this author Sung Kyu Hong More articles by this author Sangchul Lee More articles by this author Jung Kwon Kim More articles by this author Cheol Kwak More articles by this author Ja Hyeon Ku More articles by this author Chang Wook Jeong More articles by this author Ji Youl Lee More articles by this author Sung Hoo Hong More articles by this author Yong-June Kim More articles by this author Eu Chang Hwang More articles by this author Tae Gyun Kwon More articles by this author Tae-Hwan Kim More articles by this author Seok Ho Kang More articles by this author Jinsoo Chung More articles by this author Jun Hyeon Nam More articles by this author Hae Seong Lee More articles by this author Jeong Keun Song More articles by this author Jeong Won Park More articles by this author Expand All Advertisement PDF downloadLoading ...