Mp44-12 Patient and Tumor Profile Differences for Early and Late Recurrences Following Radical Resection for High-Risk Renal Cell Carcinoma

You have accessJournal of UrologyKidney Cancer: Localized: Surgical Therapy III (MP44)1 May 2024MP44-12 PATIENT AND TUMOR PROFILE DIFFERENCES FOR EARLY AND LATE RECURRENCES FOLLOWING RADICAL RESECTION FOR HIGH-RISK RENAL CELL CARCINOMA Yudai Ishiyama, Tsunenori Kondo, Kazuhiko Yoshida, Junpei Iizuka, and Toshio Takagi Yudai IshiyamaYudai Ishiyama , Tsunenori KondoTsunenori Kondo , Kazuhiko YoshidaKazuhiko Yoshida , Junpei IizukaJunpei Iizuka , and Toshio TakagiToshio Takagi View All Author Informationhttps://doi.org/10.1097/01.JU.0001009508.69111.d0.12AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Observation strategies following radical resection for renal cell carcinoma (RCC) are complex due to the mixed timing of recurrence, sometimes after 5 years of recurrence-free. This study aimed to verify whether characteristic differences exist in the population recurring in the earlier and later periods of observation. METHODS: A prospectively generated multi-institutional database was used to investigate 449 patients who underwent radical resection for high-risk RCC (pT3 or higher and/or pN+) and were sufficiently followed for 60 months. Patients were classified into four groups: No-recurrence, Early-recurrence (within 24 months), Intermediate-recurrence (24-60 months), and Late-recurrence (after 60 months). We compared patient and tumor characteristics between groups. Additionally, we compared recurrence patterns based on risk model groups (low, intermediate, and high risk). RESULTS: The four groups included 231 (51.4%), 148 (33.0%), 37 (8.2), and 33 (7.3%) patients, respectively. There were significant differences between Early-recurrence and No-recurrence or Early-recurrence and Late-recurrence in terms of the presence of symptoms, ECOG-performance status, pT stage, pN stage, tumor grade, and tumor size (all, p<0.01). However, no such difference was observed between No-recurrence and Late-recurrence. There were no significant differences between any groups for sex or histology (clear cell or non-clear cell). For recurrence patterns, in the low-risk group, 28.2% of patients who remained recurrence-free eventually recurred thereafter, while the percentage was 23.8% for intermediate and 14.3% for high-risk groups. CONCLUSIONS: Our results indicate that recurrence timing and pattern may differ depending on patient and tumor profile. While strict observation is mandatory in highest-risk cases with worse profiles, long-term follow-up after 5 years may be necessary for those with lower risk. Download PPTDownload PPT Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e735 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Yudai Ishiyama More articles by this author Tsunenori Kondo More articles by this author Kazuhiko Yoshida More articles by this author Junpei Iizuka More articles by this author Toshio Takagi More articles by this author Expand All Advertisement PDF downloadLoading ...