Pd53-11 Deferoxamine Mesylate Has the Potential to Rescue the Decline in Sperm Quality Caused by Adenine-Induced Chronic Kidney Disease

You have accessJournal of UrologyInfertility: Basic Research & Pathophysiology (PD53)1 May 2024PD53-11 DEFEROXAMINE MESYLATE HAS THE POTENTIAL TO RESCUE THE DECLINE IN SPERM QUALITY CAUSED BY ADENINE-INDUCED CHRONIC KIDNEY DISEASE YiKai Chang, Chen-Yu Lin, and ShingHwa Liu YiKai ChangYiKai Chang , Chen-Yu LinChen-Yu Lin , and ShingHwa LiuShingHwa Liu View All Author Informationhttps://doi.org/10.1097/01.JU.0001009456.01770.91.11AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Adenine-induced chronic kidney disease is a commonly used model for studying chronic kidney conditions. However, previous research did not investigate whether this model affects spermatogenic function. Kidney diseases can potentially affect organs throughout the body. We utilized adenine to induce a chronic kidney disease model in animals, observing whether renal impairment leads to reduced spermatogenic function. The question is whether restoration is possible through improving kidney function. METHODS: Male 6-week-old C57BL/6J mice were randomly allocated to the four groups: a control, adenine, adenine plus deferoxamine mesylate (DFO) Intraperitoneal injection or IP, adenine and DFO gavage diet for 4 weeks (control, AD, ADDFIP, or ADDFG, respectively); an adenine diet for 4 weeks. RESULTS: We observed that mice fed with adenine showed significantly lighter body weight, and their kidney function was much worse compared to the control group. The testes were also smaller, and sperm quality, including sperm concentration and motility, was lower compared to the control group. These conditions were markedly improved in both the DFO oral gavage and DFO intraperitoneal injection groups. CONCLUSIONS: The adenine-induced chronic kidney disease model may indeed affect the spermatogenic function of animals.DFO treatment both IP or gavage effectively improved the chronic kidney disease caused by adenine, leading to significant improvements in both renal function and reproductive capabilities in mice. Download PPTDownload PPTDownload PPTDownload PPT Source of Funding: Self funded © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e1142 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information YiKai Chang More articles by this author Chen-Yu Lin More articles by this author ShingHwa Liu More articles by this author Expand All Advertisement PDF downloadLoading ...