Pd28-05 Age Specific Calculated Free Testosterone Ranges in Adult Men

You have accessJournal of UrologySexual Function/Dysfunction: Evaluation I (PD28)1 May 2024PD28-05 AGE SPECIFIC CALCULATED FREE TESTOSTERONE RANGES IN ADULT MEN Jonathan Dokter, Bernadette Zwanns, and Hamza Beano Jonathan DokterJonathan Dokter , Bernadette ZwannsBernadette Zwanns , and Hamza BeanoHamza Beano View All Author Informationhttps://doi.org/10.1097/01.JU.0001009380.44020.d3.05AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Measurement of free testosterone (FT) levels can be an important step in the evaluation of men with suspected testosterone deficiency. While it is well known that FT levels decline with age, its clinical utility is limited due to the lack of data on age specific reference ranges. This study aimed to provide age specific reference ranges for FT to assist in the evaluation of men with suspected testosterone deficiency. METHODS: The 2013-2016 National Health and Nutrition Examination Survey was used to collect data on a nationally representative sample of men in the United States. Men were included in the analysis if they were ≥20 years old and had total testosterone labs available that were drawn in the morning (between 6 and 10 a.m.). Men were excluded from the study if they had a BMI>30, serum creatinine>1.5, AST or ALT>1.5 times the upper limit of normal, history of diabetes mellitus, testicular cancer, thyroid disease, or were on hormonal medications. FT levels were calculated using total testosterone, sex hormone binding globulin levels and albumin. Age specific ranges were separated into 10-year intervals, with exception of the final interval being all men ≥80 years old. RESULTS: 1,147 men were included in our final cohort. For each age category, we observed large differences in individual FT levels (Table 1). The highest levels of FT were observed in the youngest category (mean 114.3 pg/mL) and declined on average 12.7% each decade to a mean of 45.8 pg/mL in men ≥80 years old. The largest decline in average FT was observed from 20s to 30s with an average decline of 16.9% (Figure 1). CONCLUSIONS: To our knowledge, this is the first study to evaluate age specific calculated FT ranges in adult men. There is a consistent decline in FT in adult men with peak FT concentrations in their 20s. The large range of FT levels within each category indicates the need for a prospective study to identify factors that contribute to declining FT levels and to aid in the clinical diagnosis of testosterone deficiency. Download PPT Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e613 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Jonathan Dokter More articles by this author Bernadette Zwanns More articles by this author Hamza Beano More articles by this author Expand All Advertisement PDF downloadLoading ...