What question did this study set out to answer?

To identify demographic, lifestyle, and clinical factors associated with variations in circulating sex hormone concentrations among community-dwelling men.

August 28, 2023Annals of Internal MedicineOpen Access

Factors Associated With Circulating Sex Hormones in Men

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Authors

RMRoss J. MarriottThe University of Western Australia KMKevin MurrayAustralian National University RARobert AdamsAdelaide Institute for Sleep Health

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Implication

Meta-analysis reveals age older than 70, higher BMI, and chronic disease associate with lower testosterone in men, indicating impaired testicular function and key covariates for clinical care.

Key Points

To identify demographic, lifestyle, and clinical factors associated with variations in circulating sex hormone concentrations among community-dwelling men.
Systematic search up to July 2019 to identify prospective cohort studies evaluating community-dwelling men with total testosterone measured via mass spectrometry.
Conducted two-stage random-effects individual participant data meta-analyses to examine sociodemographic, lifestyle, and health associations with total testosterone, sex hormone-binding globulin, and luteinizing hormone.
Testosterone exhibited negligible change between ages 17 and 70 years (change per SD, -0.27 nmol/L [-7.8 ng/dL]; 95% CI, -0.71 to 0.18 nmol/L), but decreased significantly after age 70 (-1.55 nmol/L [-44.7 ng/dL]; 95% CI, -2.05 to -1.06 nmol/L).
Body mass index showed a strong inverse association with testosterone (change per SD, -2.42 nmol/L [-69.7 ng/dL]; 95% CI, -2.70 to -2.13 nmol/L), while diabetes (mean difference, -1.43 nmol/L; 95% CI, -1.65 to -1.22) and cancer (-1.39 nmol/L; 95% CI, -1.79 to -0.99) were also linked to marked reductions.
Sex hormone-binding globulin associated directly with age and inversely with body mass index, whereas luteinizing hormone increased directly with age in men older than 70 years.

Cite This Study

Marriott et al. (2023) studied this question.

synapsesocial.com/papers/6a7379aeac21afd3a771aeec https://doi.org/10.7326/m23-0342

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Implication

Meta-analysis reveals age older than 70, higher BMI, and chronic disease associate with lower testosterone in men, indicating impaired testicular function and key covariates for clinical care.

Factors Associated With Circulating Sex Hormones in Men

Discussion

Member takes

Implication

Key Points

Cite This Study

Factors Associated With Circulating Sex Hormones in Men

Discussion

Member takes

Implication

Key Points

Cite This Study

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