Mp75-10 Nocturia Across the Heart Failure Continuum: Results From an Outpatient Urology Population

You have accessJournal of UrologyUrodynamics/Lower Urinary Tract Dysfunction/Female Pelvic Medicine: Non-neurogenic Voiding Dysfunction (Excluding OAB) (MP75)1 May 2024MP75-10 NOCTURIA ACROSS THE HEART FAILURE CONTINUUM: RESULTS FROM AN OUTPATIENT UROLOGY POPULATION Samuel Yim, Alexander Fang, Lennox R. Ksido, Melica Morris, Banahene Glover, Syed N. Rahman, Jeffrey P. Weiss, Gulzhan Tologonova, Karel Everaert, Tine DeBacker, Marie-Claire Roberts, Louis Salciccioli, Jason M. Lazar, and Thomas F. Monaghan Samuel YimSamuel Yim , Alexander FangAlexander Fang , Lennox R. KsidoLennox R. Ksido , Melica MorrisMelica Morris , Banahene GloverBanahene Glover , Syed N. RahmanSyed N. Rahman , Jeffrey P. WeissJeffrey P. Weiss , Gulzhan TologonovaGulzhan Tologonova , Karel EveraertKarel Everaert , Tine DeBackerTine DeBacker , Marie-Claire RobertsMarie-Claire Roberts , Louis SalciccioliLouis Salciccioli , Jason M. LazarJason M. Lazar , and Thomas F. MonaghanThomas F. Monaghan View All Author Informationhttps://doi.org/10.1097/01.JU.0001008676.21744.5f.10AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Heart failure (HF) is increasingly viewed as a progressive disorder, with risk factors for cardiac dysfunction (Stage A) and resultant structural heart disease (Stage B) preceding the eventual development of clinical symptoms (Stages C/D) (Heidenreich, Circulation 2022). Nocturia is highly common in patients with symptomatic HF but remains poorly characterized across the HF continuum (Siniorakis, Int J Cardiol 2008). We aimed to characterize nocturia across the stages of HF in a clinical urology population. METHODS: Retrospective analysis of voiding diaries and clinical data from adult men treated for LUTS at a US Veterans Affairs outpatient urology clinic from 2008-2022. HF stage was adjudicated according to AHA/ACC guidelines by 2 expert cardiologists blinded to nocturia frequency, based on relevant risk factors, comorbidities, clinical presentation of HF symptoms, and available cardiac imaging studies (Gidding, Circ Heart Fail 2019). Stage 0 and Stage A were defined as the absence or presence of established HF risk factors such as obesity (≥30 kg/m2), metabolic syndrome, hypertension, diabetes mellitus, or coronary/peripheral artery disease. Stage B was defined as Stage A criteria +≥1 cardiac structural or functional abnormality: moderate-to-severe valvular heart disease, left ventricular hypertrophy or ejection fraction <50%, or a regional wall motion abnormality. Stages C/D required Stage B criteria+documented signs/symptoms of HF. Poisson regression was used to predict nocturia frequency based on HF stage and other parameters associated with nocturia and not directly reflected in HF staging, including age, race, edema, diuretic use, BPH, and CKD. RESULTS: A total of 328 subjects were included (Table 1). HF stage and the presence of edema were independent predictors of increasing nocturia frequency—greatest in HF Stage B (Table 2). CONCLUSIONS: Nocturia is independently associated with progressive HF stages and greatest in Stage B patients. Nocturia may serve as a useful marker for structural heart disease prior to the onset of HF symptoms. Source of Funding: N/A © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e1235 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Samuel Yim More articles by this author Alexander Fang More articles by this author Lennox R. Ksido More articles by this author Melica Morris More articles by this author Banahene Glover More articles by this author Syed N. Rahman More articles by this author Jeffrey P. Weiss More articles by this author Gulzhan Tologonova More articles by this author Karel Everaert More articles by this author Tine DeBacker More articles by this author Marie-Claire Roberts More articles by this author Louis Salciccioli More articles by this author Jason M. Lazar More articles by this author Thomas F. Monaghan More articles by this author Expand All Advertisement PDF downloadLoading ...