Mp51-04 Prognostic Value of Insulin-Like Growth Factor-I and Its Binding Proteins-Based in Patients Treated With Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma

You have accessJournal of UrologyKidney Cancer: Epidemiology & Evaluation/Staging/Surveillance II (MP51)1 May 2024MP51-04 PROGNOSTIC VALUE OF INSULIN-LIKE GROWTH FACTOR-I AND ITS BINDING PROTEINS-BASED IN PATIENTS TREATED WITH RADICAL NEPHROURETERECTOMY FOR UPPER TRACT UROTHELIAL CARCINOMA Mehdi Kardoust Parizi, Morgan Rouprêt, Jeremy Yuen-Chun Teoh, Peter Nyirády, Piotr Chlosta, Mohammad Abufaraj, Vitaly Margulis, Marek Babjuk, Ekaterina Laukhtina, and Shahrokh F. Shariat Mehdi Kardoust PariziMehdi Kardoust Parizi , Morgan RouprêtMorgan Rouprêt , Jeremy Yuen-Chun TeohJeremy Yuen-Chun Teoh , Peter NyirádyPeter Nyirády , Piotr ChlostaPiotr Chlosta , Mohammad AbufarajMohammad Abufaraj , Vitaly MargulisVitaly Margulis , Marek BabjukMarek Babjuk , Ekaterina LaukhtinaEkaterina Laukhtina , and Shahrokh F. ShariatShahrokh F. Shariat View All Author Informationhttps://doi.org/10.1097/01.JU.0001009492.49624.4b.04AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: To evaluate the predictive and prognostic value of insulin-like growth factor-I (IGF-1), insulin-like growth factor-I binding protein-2 (IGFBP-2), and -3 (IGFBP-3) in patients treated with radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC). METHODS: This is a retrospective analysis of multi-institutional database of 753 patients who underwent RNU for UTUC. The cohort was split into low and high plasma biomarkers using the median cutoff value of biomarkers. Logistic and Cox regression analyses were performed with respect to clinicopathologic endpoints. The discriminative ability of the models and the additive discriminative value of biomarkers was assessed by calculating the lasso regression test, area under receiver operating characteristics curves, C-index, and decision curve analysis (DCA). RESULTS: Higher preoperative plasma IGFBP-2 and -3 levels were independently associated with decreased risk of lymph node involvement, pT3/4 disease, and non-organ confined disease (p<0.05 for each). Preoperative higher plasma IGFBP-2 and -3 levels were independently associated with better recurrence-free survival (RFS) (HR, 0.99 and 0.93; p<0.001), cancer-specific survival (CSS) (HR, 0.99 and 0.92; p<0.001), and overall survival (OS) (HR, 0.99 and 0.95; p<0.001) in multivariable models, respectively. The addition of both IGFBP-2 and -3 to a base multivariable model improved the model's concordance index by 10%, 9%, and 8% for RFS, CSS, and OS, respectively. On DCA adding IGFBP-2 and -3 to these predictive models improved their discriminatory ability to predict RFS, CSS, and OS by a significant margin. CONCLUSIONS: We confirmed that an elevated plasma levels of IGFBP-2 and -3 both are independent and clinically significant predictors of oncologic outcomes and adverse pathological features in UTUC patients treated with RNU. These findings might help guide the clinical decision-making regarding adjuvant systemic therapy and follow-up scheduling. Download PPTDownload PPT Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e842 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Mehdi Kardoust Parizi More articles by this author Morgan Rouprêt More articles by this author Jeremy Yuen-Chun Teoh More articles by this author Peter Nyirády More articles by this author Piotr Chlosta More articles by this author Mohammad Abufaraj More articles by this author Vitaly Margulis More articles by this author Marek Babjuk More articles by this author Ekaterina Laukhtina More articles by this author Shahrokh F. Shariat More articles by this author Expand All Advertisement PDF downloadLoading ...