Mp46-20 the Safety and Efficacy of Addition of Gentamicin on Irrigation Fluid in Prevention of Post-Transurethral Resection of the Prostate Infectious Complications: A Prospective Randomized Double Blinded Placebo Controlled Trial

You have accessJournal of UrologyBenign Prostatic Hyperplasia: Surgical Therapy "Group A" included 110 patients who had undergone TURP with addition of one ampoule of gentamicin 80 mg (2ml) /3L of irrigation solution (the first 9 Liters during resection and the first 6 Liters during post-operative irrigation) and "Group B" included 110 patients who had underwent TURP with addition of normal saline (2 ml) as a placebo on the irrigation solution. Determination of Gentamicin in human serum using HPLC/UV after Chemical Derivatization was done using the method of Barends et al (Barends, Brouwers, & Hulshoff, 1987). Both groups were compared as regards the demographic data, post-operative pyuria and bacteruria (1 week after removal of urethral catheter), fever, and/or sepsis. RESULTS: The demographic data were comparable in both groups. The mean operative time was 58.95±7.92 and 58.58±8.90 minutes in groups A and B, respectively. No significant changes between pre-and post-operative serum creatinine in both groups. The applied method could not detect any amount of gentamicin in the serum of the tested patients. These results indicated that gentamicin was either not absorbed or was circulating in the blood stream with concentrations lower than the limit of quantitation (that could be neglected and wouldn't induce neither therapeutic effect nor side effects). Post-operative pyuria (1 week after urethral catheter) occurred in 8.2 % in group A versus 20.9% in group B (P=0.007). Post-operative bacteruria was observed in 7 patients (6.3 %) in group A versus 22 patients (20 %) in group B (p value<0.001). febrile UTI occurred in 3 patients in group A versus 7 patients in group B. Sepsis occurred in two patients in group B. CONCLUSIONS: The addition of gentamicin on the irrigation solution during and after TURP is safe and significantly associated with reduction of postoperative pyuria, bacteruria and febrile UTI. Further studies are needed to confirm our findings. Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e761 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Ahmed Zoeir More articles by this author Ayman Mousa More articles by this author Hussein Mamdoh More articles by this author Talaat Zaghloul More articles by this author Tarek Gameel More articles by this author Maged Ragab More articles by this author Mohamed Abo-Elenein More articles by this author Mansour R. Fotouh More articles by this author Ahmed Eissa More articles by this author Expand All Advertisement PDF downloadLoading ...