Mp46-16 Efficacy of Warm Irrigation Solution in Improving Perioperative Outcomes in Patients Undergoing Transurethral Resection of Prostate: A Prospective Parallel Arm Single Blinded Randomized Control Trial

You have accessJournal of UrologyBenign Prostatic Hyperplasia: Surgical Therapy & New Technology III (MP46)1 May 2024MP46-16 EFFICACY OF WARM IRRIGATION SOLUTION IN IMPROVING PERIOPERATIVE OUTCOMES IN PATIENTS UNDERGOING TRANSURETHRAL RESECTION OF PROSTATE: A PROSPECTIVE PARALLEL ARM SINGLE BLINDED RANDOMIZED CONTROL TRIAL Manoj Kumar Das, Prasant Nayak, Swarnendu Mandal, Prasanna Ram, Sambit Tripathy, Kirti Singh, and Vivek Tarigopula Manoj Kumar DasManoj Kumar Das , Prasant NayakPrasant Nayak , Swarnendu MandalSwarnendu Mandal , Prasanna RamPrasanna Ram , Sambit TripathySambit Tripathy , Kirti SinghKirti Singh , and Vivek TarigopulaVivek Tarigopula View All Author Informationhttps://doi.org/10.1097/01.JU.0001008668.53858.38.16AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Perioperative bleeding continues to be major morbidity of transurethral resection of the prostate (TURP). Various techniques tried to reduce blood loss in TURP. This study aims to determine the efficacy of warm irrigation solution(37°C) in improving intraoperative bleeding and perioperative outcomes of TURP surgery. METHODS: This is an interim analysis of a Single-blind, parallel-arm, randomized controlled trial (CTRI/2022/09/045235) done from August 2022 to June 2023. All patients undergoing TURP were included. Patients with uncontrolled hypertension, cardiac disease, and on anticoagulants were excluded. The study group received warm irrigation solution(37°C), whereas the control group received room temperature irrigation solution throughout the procedure. Intraoperative blood loss was the primary outcome. The secondary outcomes were mean postoperative pain score (at 1 h, 6h,24h) (Universal pain assessment score), analgesic requirement, and post-op UTI. incidence of hypothermia, requirement of blood transfusion, ease during surgery, post-op IPSS score at POD 10 and length of hospitalization (LOH). RESULTS: Based on the deemed sample size 27 patients were planned to be included in each group on interim analysis, and 15 patients were included in each group. Demographic and clinical profiles were comparable in both groups. The mean blood loss in the study group was significantly lower than the control group [65(58-70) ml vs 82(78-108) ml; p<0.001 ]. Incidence of hypothermia was significantly lower in the study group (6.6% vs 73.3%; p=0.001) also ease of surgery was better with warm saline as less frost and so less need to clear the eyepiece thus significantly decreasing the resection time(58.46±11.15 minutes vs 89.13±24.81; p=0.019). Rest of the secondary outcomes; mean indwelling catheter time (p=0.94), postoperative complications (p=0.73), and LOH (p=0.87) were comparable in both groups. CONCLUSIONS: In this interim analysis, warm irrigation solution(37°C) significantly reduced intraoperative blood loss and hypothermia; and improved vision and thereby significantly decreasing the time of resection. Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e759 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Manoj Kumar Das More articles by this author Prasant Nayak More articles by this author Swarnendu Mandal More articles by this author Prasanna Ram More articles by this author Sambit Tripathy More articles by this author Kirti Singh More articles by this author Vivek Tarigopula More articles by this author Expand All Advertisement PDF downloadLoading ...