Mp52-17 Radical Prostatectomy for Non-Metastatic Prostate Cancer in Renal Transplant Recipients: Outcomes From a Large Contemporary Cohort and Matched-Paired Analysis With Non-Transplanted Patients

You have accessJournal of UrologyProstate Cancer: Localized: Surgical Therapy II (MP52)1 May 2024MP52-17 RADICAL PROSTATECTOMY FOR NON-METASTATIC PROSTATE CANCER IN RENAL TRANSPLANT RECIPIENTS: OUTCOMES FROM A LARGE CONTEMPORARY COHORT AND MATCHED-PAIRED ANALYSIS WITH NON-TRANSPLANTED PATIENTS Alessandro Marquis, Stefano Tappero, Francesco Barletta, Marco Allasia, Marco Oderda, Charles Dariane, Marc-Olivier Timsit, Julien Branchereau, Benoit Mesnard, Derya Tilki, Jonathon Olsburgh, Meghana Kulkarni, Veeru Kasivisvanathan, Cedric Lebacle, Alberto Breda, Antonio Galfano, Giorgio Gandaglia, Alberto Briganti, Francesco Montorsi, Luigi Biancone, Paolo Gontero, and Giancarlo Marra Alessandro MarquisAlessandro Marquis , Stefano TapperoStefano Tappero , Francesco BarlettaFrancesco Barletta , Marco AllasiaMarco Allasia , Marco OderdaMarco Oderda , Charles DarianeCharles Dariane , Marc-Olivier TimsitMarc-Olivier Timsit , Julien BranchereauJulien Branchereau , Benoit MesnardBenoit Mesnard , Derya TilkiDerya Tilki , Jonathon OlsburghJonathon Olsburgh , Meghana KulkarniMeghana Kulkarni , Veeru KasivisvanathanVeeru Kasivisvanathan , Cedric LebacleCedric Lebacle , Alberto BredaAlberto Breda , Antonio GalfanoAntonio Galfano , Giorgio GandagliaGiorgio Gandaglia , Alberto BrigantiAlberto Briganti , Francesco MontorsiFrancesco Montorsi , Luigi BianconeLuigi Biancone , Paolo GonteroPaolo Gontero , and Giancarlo MarraGiancarlo Marra View All Author Informationhttps://doi.org/10.1097/01.JU.0001008864.84854.b7.17AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Whether renal transplant recipient (RTR) status might affect radical prostatectomy (RP) outcomes is unknown. The current study aims to compare RTR vs non-RTR treated with RP for cN0M0 prostate cancer (PCa), in terms of cancer-control and mortality outcomes (primary outcomes) and peri- and post-operative functional outcomes (secondary outcomes). METHODS: RTR undergone RP at seven European institutions (2001-2022) were identified. A multi-institutional cohort of non-RTR treated with RP (2004-2022) served as comparative group. Propensity score matching (PSM) with 1:4 ratio was performed between RTR vs non-RTR. Matching variables consisted of age at RP, PSA, and final pathology features. Kaplan-Meier plots, multivariable Cox, logistic and Poisson log-linear regression models tested the outcomes of interest. RESULTS: After PSM, 102 RTR vs 408 non-RTR were analyzed. RTR experienced higher estimated blood loss (EBL; 400 vs 200 mL), longer hospital stay (LOS; 6 vs 3.5 days) and time to catheter removal (11 vs 5 days), higher rates of 30-day postoperative complications (27 vs 12%) and lower continence recovery at six months (75 vs 89%; all p values <0.001). On multivariable analysis RTR independently predicted unfavorable operative time, LOS, EBL and time to bladder catheter removal (rate ratios between 1.22 and 2.24; all p values <0.001), but not complications or continence. RTR did not significantly differ from non-RTR in terms of any cancer-control outcome (biochemical recurrence: 11 vs 11%; local recurrence: 2 vs 1%; systemic progression: 2 vs 0%; all p values ≥0.1). Whilst no PCa deaths were recorded, RTR experienced significantly higher overall mortality (OM; 17 vs 0.5%; p<0.001). CONCLUSIONS: RTR status affects RP surgical outcomes. Conversely, no significant differences between RTR vs non-RTR were recorded in terms of complications, continence and oncological outcomes. RTR experienced significantly higher OM, related to other cause than PCa. The current study suggests that RP in RTR, albeit feasible, poses non-negligible surgical challenges. Besides, RTR have invariably reduced life expectancy. Therefore, patient selection should be carefully performed for RTR candidates to RP. Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e860 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Alessandro Marquis More articles by this author Stefano Tappero More articles by this author Francesco Barletta More articles by this author Marco Allasia More articles by this author Marco Oderda More articles by this author Charles Dariane More articles by this author Marc-Olivier Timsit More articles by this author Julien Branchereau More articles by this author Benoit Mesnard More articles by this author Derya Tilki More articles by this author Jonathon Olsburgh More articles by this author Meghana Kulkarni More articles by this author Veeru Kasivisvanathan More articles by this author Cedric Lebacle More articles by this author Alberto Breda More articles by this author Antonio Galfano More articles by this author Giorgio Gandaglia More articles by this author Alberto Briganti More articles by this author Francesco Montorsi More articles by this author Luigi Biancone More articles by this author Paolo Gontero More articles by this author Giancarlo Marra More articles by this author Expand All Advertisement PDF downloadLoading ...