Mp28-04 Redefining Peyronie’s Disease and Penile Curvature Using Evidence-Based Criteria

You have accessJournal of UrologySexual Function/Dysfunction: Peyronie's Disease (MP28)1 May 2024MP28-04 REDEFINING PEYRONIE'S DISEASE AND PENILE CURVATURE USING EVIDENCE-BASED CRITERIA Landon Trost, John Mulhall, and Wayne Hellstrom Landon TrostLandon Trost , John MulhallJohn Mulhall , and Wayne HellstromWayne Hellstrom View All Author Informationhttps://doi.org/10.1097/01.JU.0001008872.42208.7a.04AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: To identify new Peyronie's disease (PD) subtypes, non-PD penile curvature classifications, and define acute versus chronic phase disease using evidence-based analyses. METHODS: A retrospective review was performed of 1,098 men who presented with penile deformity, including subjective standardized and non-standardized questionnaires and objective measures. Statistical analyses were performed to identify clusters of disease characteristics representative of distinct PD and non-PD categorizations. Sensitivity/specificity analyses were also performed to more accurately characterize the acute vs chronic phase of disease. RESULTS: Comparative analyses identified four distinct subtypes of PD: Calcifying (moderate/severe calcification), Classical (non-Progressive, non-Calcifying, non-Traumatic), Progressive (subjective worsening following disease onset), and Relapsing/Remitting (reactivation following≥6 month period of stability). Penile pain was found to be an inferior predictor to subjective worsening of the condition for both Progressive PD as well as acute phase definitions. Among non-PD curvatures, additional categorizations were created/differentiated including Congenital (lifelong), Maturational (developed at puberty), and Trauma-induced. Statistical analyses demonstrated unique profiles among each categorization, including differences in patient age, disease duration and stability, progression, penile length/shortening and pain, curve direction and degree, indentation/hourglass deformities, and calcification. Acute phase disease was defined as subjective worsening of the condition, with 1-month following onset found to be the optimal timepoint to differentiate Progressive vs non-progressive disease: sensitivity (86.1%), specificity (60.1%), positive predictive value (71.4%) and negative predictive value (78.8%). CONCLUSIONS: The current study provides an evidence-based proposal for the establishment of new PD subtypes and non-PD curvature categorizations as well as a standardized definition for acute-phase disease. Source of Funding: Internal © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e473 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Landon Trost More articles by this author John Mulhall More articles by this author Wayne Hellstrom More articles by this author Expand All Advertisement PDF downloadLoading ...