Pd17-06 Assessment of Psma Pet/Ct Findings in Patients Undergoing Radical Prostatectomy for Isup Grade Group 1 Prostate Cancer

You have accessJournal of UrologyProstate Cancer: Staging I (PD17)1 May 2024PD17-06 ASSESSMENT OF PSMA PET/CT FINDINGS IN PATIENTS UNDERGOING RADICAL PROSTATECTOMY FOR ISUP GRADE GROUP 1 PROSTATE CANCER Felix Preisser, Florian Nohe, Tobias Maurer, Markus Graefen, and Derya Tilki Felix PreisserFelix Preisser , Florian NoheFlorian Nohe , Tobias MaurerTobias Maurer , Markus GraefenMarkus Graefen , and Derya TilkiDerya Tilki View All Author Informationhttps://doi.org/10.1097/01.JU.0001010044.70939.31.06AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: To assess the performance of Prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) as local staging in radical prostatectomy (RP) patients with ISUP grade group 1 prostate cancer (PCa) at biopsy. METHODS: 78 RP patients with ISUP grade group 1 PCa at biopsy who underwent staging PSMA PET/CT were identified. Pathologic characteristics during RP according to PSMA findings were assessed. Adverse pathology was defined as ISUP grade group 3 at RP or non-organ confined disease. RESULTS: Of the 78 patients, only 11 (14.1%) had ISUP 1 at final pathology. 48 (61.5%), 14 (17.9%) and 3 (3.8%) had an upgrading to ISUP 2, ISUP 3 and ISUP 4-5, respectively. Median SUVmax in the prostate was 7 at PSMA PET/CT. Median PSA was 11.1 ng/ml. Most (67.9%) patients had organ confined disease at final pathology. Patients with vs. without adverse pathology (n=30) had a significantly higher median SUVmax (14.3 vs 5.3, IQR: 6.2-23.9 vs. 3.4-9, p<0.01). No difference in median PSA between patients with and without adverse pathology was recorded (p=0.2). CONCLUSIONS: Intraprostatic PSMA uptake was found to be associated with adverse pathology at the time of radical prostatectomy in patients with biopsy ISUP grade 1. Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e372 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Felix Preisser More articles by this author Florian Nohe More articles by this author Tobias Maurer More articles by this author Markus Graefen More articles by this author Derya Tilki More articles by this author Expand All Advertisement PDF downloadLoading ...