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You have accessJournal of UrologyProstate Cancer: Basic Research we found an important interaction between DOT1L-nMYC, which is centrally regulated by E2 ligases within NEPC stem cells. We demonstrated that ALDH+ tumor grafts subjected to GSNO treatment could increase the E2 ligases and, therefore, inhibit DOT1L and nMYC. CONCLUSIONS: This study shows that exogenous treatment with nitric oxide donor suppresses the NEPC stem cells and the expression of MYC and DOT1L in these cells by increasing the ubiquitin ligases. Source of Funding: American Cancer Society; Sylvester Cancer Center © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e726 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Fakiha Firdaus More articles by this author Osmel Companioni Napoles More articles by this author Khushi Shah More articles by this author Ranjith Ramasamy More articles by this author Himanshu Arora More articles by this author Expand All Advertisement PDF downloadLoading ...
Firdaus et al. (2024) studied this question.