Pd37-05 Intrauterine Insemination Success Rates for Men With Low Post-Wash Total Progressively Motile Sperm Counts

You have accessJournal of UrologyInfertility: Epidemiology & Evaluation II (PD37)1 May 2024PD37-05 INTRAUTERINE INSEMINATION SUCCESS RATES FOR MEN WITH LOW POST-WASH TOTAL PROGRESSIVELY MOTILE SPERM COUNTS Daniel Pelzman, Claire Haas, Shunping Wang, Jay Sandlow, and Peter Dietrich Daniel PelzmanDaniel Pelzman , Claire HaasClaire Haas , Shunping WangShunping Wang , Jay SandlowJay Sandlow , and Peter DietrichPeter Dietrich View All Author Informationhttps://doi.org/10.1097/01.JU.0001009464.98066.03.05AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: A post-wash total motile sperm count (TMC) of 5 million has traditionally been used as a recommended cutoff for proceeding with an intrauterine insemination (IUI) cycle. However, no studies have evaluated the use of post-wash total progressively motile count (pwTPMC). We sought to evaluate IUI success rates and the impact of female partner age for men with pwTPMC between 1 and 5 million versus those with pwTPMC >5 million. METHODS: We performed a retrospective analysis of all IUI cycles at our institution from April 2015 to October 2023. Semen analysis parameters, demographic information, IUI cycle type, and pregnancy data were obtained. The primary outcome of interest was pregnancy rate determined by either biochemical pregnancy or positive fetal heart monitor. Subgroups based on female age of 35 and pwTPMC (threshold 5 million) were created. Pregnancy rates were compared among groups using Chi-squared test. RESULTS: A total of 3,951 cycles were analyzed with a mean female age of 33.4 years. Of these, 1,195 were females >35 years and 2,756 were females ≤35 years. Success rates for females aged 35 and under were similar in the 1-5 million and ≥5 million pwTPMC groups (13.7% vs 16.6%, p=0.9). Success rates for females over >35 were significantly lower in the 1-5 million pwTPMC group compared to>5 million TPMC group (4.8% vs 13.6%, p<0.05). Within the 1-5 million pwTPMC and female age ≤35 cohort, lower TPMC (i.e. closer to 1 million) did not portend worse pregnancy success rates. CONCLUSIONS: In couples with a female age ≤35, pwTPMC of 1-5 million was not associated with worse pregnancy rates compared to a pwTPMC of ≥5 million. However, if female age was >35, a significant decline in pregnancy rates was observed with pwTPMC of 1-5 million. These results suggest that low pwTPMC yields acceptable pregnancy rates in women ≤35, but those >35 should be appropriately counseled about lower pregnancy rates. Download PPT Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e801 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Daniel Pelzman More articles by this author Claire Haas More articles by this author Shunping Wang More articles by this author Jay Sandlow More articles by this author Peter Dietrich More articles by this author Expand All Advertisement PDF downloadLoading ...