Pd09-10 Unique Characteristics of Japanese Patients With Rare Ductal Adenocarcinoma of the Prostate: A Genomic Analysis

You have accessJournal of UrologyProstate Cancer: Basic Research 21.4%) and Wnt-β catenin pathway (n=6; 42.9%) was comparable, but no alterations in the DNA damage repair (DDR) pathway were observed. None of the patients presented high tumor mutation burden or microsatellite instability. CONCLUSIONS: We found that the Japanese cohort with ductal adenocarcinoma has unique features such as high frequency of alterations in tumor suppressor gene such as TP53 and RB1, and lack DDR pathway alterations, suggesting the existence of regional and racial differences in genomic profiles. Genomic analysis using next-generation sequencing is expected to be useful in elucidating the pathogenesis of ductal adenocarcinoma, and further accumulation of cases is considered important. Source of Funding: This work was supported in part by a Grant-in-Aid for Scientific Research (23K15793 to Hiroaki Kobayashi) from the Ministry of Education, Culture, Sports, Science, and Technology of Japan © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e183 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Hiroaki Kobayashi More articles by this author Takeo Kosaka More articles by this author Kohei Nakamura More articles by this author Tokuhiro Kimura More articles by this author Kosuke Miyai More articles by this author Yuto Baba More articles by this author Yota Yasumizu More articles by this author Kazuhiro Matsumoto More articles by this author Hiroshi Nishihara More articles by this author Hitoshi Tsuda More articles by this author Susumu Matsukuma More articles by this author Mototsugu Oya More articles by this author Keiichi Ito More articles by this author Expand All Advertisement PDF downloadLoading ...