Pd09-10 Unique Characteristics of Japanese Patients With Rare Ductal Adenocarcinoma of the Prostate: A Genomic Analysis

You have accessJournal of UrologyProstate Cancer: Basic Research & Pathophysiology II (PD09)1 May 2024PD09-10 UNIQUE CHARACTERISTICS OF JAPANESE PATIENTS WITH RARE DUCTAL ADENOCARCINOMA OF THE PROSTATE: A GENOMIC ANALYSIS Hiroaki Kobayashi, Takeo Kosaka, Kohei Nakamura, Tokuhiro Kimura, Kosuke Miyai, Yuto Baba, Yota Yasumizu, Kazuhiro Matsumoto, Hiroshi Nishihara, Hitoshi Tsuda, Susumu Matsukuma, Mototsugu Oya, and Keiichi Ito Hiroaki KobayashiHiroaki Kobayashi , Takeo KosakaTakeo Kosaka , Kohei NakamuraKohei Nakamura , Tokuhiro KimuraTokuhiro Kimura , Kosuke MiyaiKosuke Miyai , Yuto BabaYuto Baba , Yota YasumizuYota Yasumizu , Kazuhiro MatsumotoKazuhiro Matsumoto , Hiroshi NishiharaHiroshi Nishihara , Hitoshi TsudaHitoshi Tsuda , Susumu MatsukumaSusumu Matsukuma , Mototsugu OyaMototsugu Oya , and Keiichi ItoKeiichi Ito View All Author Informationhttps://doi.org/10.1097/01.JU.0001008572.33286.63.10AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Genomic profile analysis using next-generation sequencing can potentially elucidate the pathogenesis of rare cancers. Ductal adenocarcinoma is a rare subtype of prostate cancer with unknown pathogenesis and poor prognosis. While some studies have investigated the genetic profile of the ductal adenocarcinoma genotype to date, no conclusive findings are available due to the small number of patients and limited geographic coverage. The discovery of novel prognostic biomarkers and identification of new pharmacotherapeutic targets for ductal adenocarcinoma are currently of research interest. The aim of this study is to analyze the genomic profile of ductal adenocarcinoma in a Japanese population and to summarize its features. METHODS: Clinical and histological records from our three hospitals were searched for radical prostatectomy, transurethral resection of the prostate, and prostate needle biopsy specimens with a ductal adenocarcinoma component in the past 10 years. We identified 27 patients diagnosed with ductal adenocarcinoma of the prostate, of whom 14 were eligible for genomic profile analysis and 10 patients (71.4%) had the pure type. Genomic assessment was performed using either the FoundationOne CDx or PleSSision testing platform. RESULTS: At least one genomic alteration occurred in 13 patients (92.9%), and the most frequently mutated gene was tumor suppressor protein p53 (TP53), which was found in six cases (42.9%). Additionally, four cases (28.9%) had mutations in retinoblastoma transcriptional corepressor 1 (RB1), and all these patients had the pure type. Three cases had both TP53 and RB1 alterations, and all of these possessed the pure type and had PSA levels of less than 4.0. Compared to previous study results, the frequency of genetic alterations in the phosphoinositide 3-kinase (PI3K) pathway (n=3; 21.4%) and Wnt-β catenin pathway (n=6; 42.9%) was comparable, but no alterations in the DNA damage repair (DDR) pathway were observed. None of the patients presented high tumor mutation burden or microsatellite instability. CONCLUSIONS: We found that the Japanese cohort with ductal adenocarcinoma has unique features such as high frequency of alterations in tumor suppressor gene such as TP53 and RB1, and lack DDR pathway alterations, suggesting the existence of regional and racial differences in genomic profiles. Genomic analysis using next-generation sequencing is expected to be useful in elucidating the pathogenesis of ductal adenocarcinoma, and further accumulation of cases is considered important. Source of Funding: This work was supported in part by a Grant-in-Aid for Scientific Research (23K15793 to Hiroaki Kobayashi) from the Ministry of Education, Culture, Sports, Science, and Technology of Japan © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e183 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Hiroaki Kobayashi More articles by this author Takeo Kosaka More articles by this author Kohei Nakamura More articles by this author Tokuhiro Kimura More articles by this author Kosuke Miyai More articles by this author Yuto Baba More articles by this author Yota Yasumizu More articles by this author Kazuhiro Matsumoto More articles by this author Hiroshi Nishihara More articles by this author Hitoshi Tsuda More articles by this author Susumu Matsukuma More articles by this author Mototsugu Oya More articles by this author Keiichi Ito More articles by this author Expand All Advertisement PDF downloadLoading ...