Mp01-07 Impact of Chemotherapy on Anxiety, Depression, and Suicidality Amongst Testicular Cancer Survivors

You have accessJournal of UrologyPenile & Testicular Cancer I (MP01)1 May 2024MP01-07 IMPACT OF CHEMOTHERAPY ON ANXIETY, DEPRESSION, AND SUICIDALITY AMONGST TESTICULAR CANCER SURVIVORS Margaret F. Meagher, Tyler Nelson, Paul Riviere, Austin Leonard, Isabella Dolendo, Kylie Morgan, Luke Wang, Jacob Taylor, Daniel Herchenhorn, Tyler Stewart, Juan Javier-Desloges, Amirali Salmasi, Rana McKay, Frederick Millard, Brent Rose, and Aditya Bagrodia Margaret F. MeagherMargaret F. Meagher , Tyler NelsonTyler Nelson , Paul RivierePaul Riviere , Austin LeonardAustin Leonard , Isabella DolendoIsabella Dolendo , Kylie MorganKylie Morgan , Luke WangLuke Wang , Jacob TaylorJacob Taylor , Daniel HerchenhornDaniel Herchenhorn , Tyler StewartTyler Stewart , Juan Javier-DeslogesJuan Javier-Desloges , Amirali SalmasiAmirali Salmasi , Rana McKayRana McKay , Frederick MillardFrederick Millard , Brent RoseBrent Rose , and Aditya BagrodiaAditya Bagrodia View All Author Informationhttps://doi.org/10.1097/01.JU.0001008660.87408.90.07AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Chemotherapy for testicular cancer (TC) is highly effective yet associated with significant consequences on long-term health-related quality of life. We evaluated the impact of chemotherapy on anxiety, depression, and suicidality amongst TC survivors. METHODS: We conducted a retrospective cohort study of US veterans diagnosed with TC from 1990-2016. These were compared to a age-matched control group of US veterans without diagnosis of TC. De novo anxiety or depression was a composite endpoint comprised of diagnosis codes for anxiety, depression, or administration of medications used to treat these diagnoses. Incident suicidality was defined as a diagnosis code for suicidal ideation. Time to event was defined as time from diagnosis to event or censor at the time of last follow-up. Rates of outcomes were reported through cumulative incidences. Associations between outcomes and receipt of chemotherapy were assessed through multivariable Cox regression models. RESULTS: 2022 patients were compared to 6,920 controls. Median follow up time was 7.67 years for surviving patients. 685 patients received chemotherapy. At 5 years, cumulative incidence of anxiety, depression or administration of medications used to treat these was 30% in the control group versus 50% in the cancer cohort (p<0.001). On multivariable Cox regression, factors associated with a higher risk of anxiety or depression were divorced status (HR 1.15, p=0.045), unemployment (HR 1.68, p<0.001), and receipt of chemotherapy (HR 1.19, p=0.015). In the cancer cohort, cumulative incidence of anxiety or depression varied by treatment: 67% chemotherapy alone, 52% chemotherapy and surgery, 37% surgery and radiation. CONCLUSIONS: Psychosocial morbidity is high among TC survivors. Despite being effective and necessary for maintaining excellent oncologic outcomes, chemotherapy appears to increase the rates of psychosocial morbidity. Clinicians should be proactive in identifying support systems for these TC survivors. Download PPTDownload PPT Source of Funding: N/A © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e4 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Margaret F. Meagher More articles by this author Tyler Nelson More articles by this author Paul Riviere More articles by this author Austin Leonard More articles by this author Isabella Dolendo More articles by this author Kylie Morgan More articles by this author Luke Wang More articles by this author Jacob Taylor More articles by this author Daniel Herchenhorn More articles by this author Tyler Stewart More articles by this author Juan Javier-Desloges More articles by this author Amirali Salmasi More articles by this author Rana McKay More articles by this author Frederick Millard More articles by this author Brent Rose More articles by this author Aditya Bagrodia More articles by this author Expand All Advertisement PDF downloadLoading ...