Mp36-16 Predicting Cardiovascular Events in Patients With Renal Cell Carcinoma Undergoing Nephrectomy: A Multicentre Hong Kong Prospective Cohort Study

You have accessJournal of UrologyKidney Cancer: Epidemiology & Evaluation/Staging/Surveillance I (MP36)1 May 2024MP36-16 PREDICTING CARDIOVASCULAR EVENTS IN PATIENTS WITH RENAL CELL CARCINOMA UNDERGOING NEPHRECTOMY: A MULTICENTRE HONG KONG PROSPECTIVE COHORT STUDY Yan Hiu Athena Yha Lee, Chi Ho Ch Leung, Jeffrey Shi Kai Jsk Chan, Xiao Bo Xb Wu, and Chi Fai Cf Ng Yan Hiu Athena Yha LeeYan Hiu Athena Yha Lee , Chi Ho Ch LeungChi Ho Ch Leung , Jeffrey Shi Kai Jsk ChanJeffrey Shi Kai Jsk Chan , Xiao Bo Xb WuXiao Bo Xb Wu , and Chi Fai Cf NgChi Fai Cf Ng View All Author Informationhttps://doi.org/10.1097/01.JU.0001008612.93052.9d.16AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Renal cell carcinoma (RCC) is associated with increased cardiovascular risk, but tools predicting cardiovascular events in these patients after nephrectomy are lacking, especially in Asians. METHODS: All patients with RCC undergoing nephrectomy in 3 regional hospitals in Hong Kong between 1992-2022 were included, excluding those with prior myocardial infarction (MI)/stroke/heart failure (HF). All patients were followed up for the outcome of major adverse cardiovascular events (MACE; a composite of MI, stroke, heart failure, and cardiovascular mortality) until 31/8/2023 or death, whichever occurred first, for a maximum of 5 years. A model predicting 5-year MACE was constructed with electronic health records-based data using Cox proportional hazards model, the discrimination and prognostic value of which were internally assessed. RESULTS: In total, 1044 patients were analyzed (mean age 60.3±12.0 years; median follow-up 5.0 years [interquartile range 2.8-5.0 years]). MACE occurred in 79 patients (7.6%). Age at nephrectomy (adjusted hazard ratio [aHR] 1.06 [95% confidence interval: 1.03-1.08], p<0.001), partial nephrectomy (aHR 0.70 [0.42-1.18], p=0.184), baseline diabetes mellitus (aHR 1.58 [0.97-2.55], p=0.064), hypertension (aHR 1.94 [1.09-3.46], p=0.025) and baseline chronic kidney disease (aHR 1.56 [0.84-2.89], p=0.159) were selected to be part of the predictive model. Within the derivation cohort, this model showed satisfactory discrimination (Harrel's c-statistic 0.755). Patients in the highest quartile of predicted risk had a significantly higher observed 5-year risk of MACE than those in the lowest quartile (log-rank p<0.001). CONCLUSIONS: A predictive model for incident MACE was constructed for Asian patients with RCC undergoing nephrectomy, achieving satisfactory discrimination and prognostic value. Further research and external validation of this model are required. Download PPT Source of Funding: Not applicable © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e598 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Yan Hiu Athena Yha Lee More articles by this author Chi Ho Ch Leung More articles by this author Jeffrey Shi Kai Jsk Chan More articles by this author Xiao Bo Xb Wu More articles by this author Chi Fai Cf Ng More articles by this author Expand All Advertisement PDF downloadLoading ...