Mp40-05 Mapping of Registered Nephrolithiasis Clinical Trials

You have accessJournal of UrologyStone Disease: Epidemiology & Evaluation I (MP40)1 May 2024MP40-05 MAPPING OF REGISTERED NEPHROLITHIASIS CLINICAL TRIALS Mohammed Shahait, Ryan Dobbs, Abdulrahman A. Alhajahjeh, Lana Batarseh, Manar Al-Zerkoshi, Adnan Al-Kababji, Timothy Averch, and Gregory E. Tasian Mohammed ShahaitMohammed Shahait , Ryan DobbsRyan Dobbs , Abdulrahman A. AlhajahjehAbdulrahman A. Alhajahjeh , Lana BatarsehLana Batarseh , Manar Al-ZerkoshiManar Al-Zerkoshi , Adnan Al-KababjiAdnan Al-Kababji , Timothy AverchTimothy Averch , and Gregory E. TasianGregory E. Tasian View All Author Informationhttps://doi.org/10.1097/01.JU.0001008788.18007.3f.05AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Nephrolithiasis is a complex disease with varying presentations, necessitating complex decision-making that encompasses choosing initial imaging, optimizing pain control, determining the best definitive management option, specifying the preferred procedure type, conducting metabolic evaluations, establishing a follow-up protocol, and implementing prevention strategies. Clinical trials serve as the cornerstone of evidence-based practice, enhancing patient outcomes, and reducing the economic burden of this condition. We sought to investigate the distribution of the focus of clinical trials in nephrolithiasis. METHODS: We queried clinicaltrials.gov to identify listed observational and randomized clinical trials focused on nephrolithiasis between January 1, 2000, and concluded before December 31, 2020. Based on authors consensus, clinical trials were categorized based on the type of intervention, and its relation to the management process into the following categories: diagnostic, active medical management, surgical intervention, preventive interventions (medical/dietary/herbal), and miscellaneous. RESULTS: We identified 202 clinical trials focused on nephrolithiasis. Of these trials, 54.4% were related to surgical intervention such as ureteral stenting, ureteroscopy, PCNL, and ESWL; 19.8% were preventive interventions, 14.8% were focused on active medical management either to control renal colic or expulsive therapy in primary and adjunct setting, and 9.4% were focused on diagnostic imaging and biomarkers. Only 6.4% (n=13) of the trials were comparing the outcomes of two different surgical interventions. CONCLUSIONS: There is a disproportionate number of trials in the surgical intervention in nephrolithiasis, while there are a few trials focused on preventive interventions. This study maps the focus of clinical trials in nephrolithiasis, which could inform research and stakeholders to identify research priorities in nephrolithiasis management. Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e664 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Mohammed Shahait More articles by this author Ryan Dobbs More articles by this author Abdulrahman A. Alhajahjeh More articles by this author Lana Batarseh More articles by this author Manar Al-Zerkoshi More articles by this author Adnan Al-Kababji More articles by this author Timothy Averch More articles by this author Gregory E. Tasian More articles by this author Expand All Advertisement PDF downloadLoading ...