Mp40-16 Do Changes in Metabolic Health and Obesity Affect the Incidence of Urolithiasis?; A Nationally Representative Cohort Study

You have accessJournal of UrologyStone Disease: Epidemiology & Evaluation I (MP40)1 May 2024MP40-16 DO CHANGES IN METABOLIC HEALTH AND OBESITY AFFECT THE INCIDENCE OF UROLITHIASIS?; A NATIONALLY REPRESENTATIVE COHORT STUDY Won Ku Hwang, Hyo Jong Kim, Seon Beom Jo, Hyun Soo Lee, Jong Wook Kim, Mi Mi Oh, Hong Seok Park, Du Geon Moon, and Sun Tae Ahn Won Ku HwangWon Ku Hwang , Hyo Jong KimHyo Jong Kim , Seon Beom JoSeon Beom Jo , Hyun Soo LeeHyun Soo Lee , Jong Wook KimJong Wook Kim , Mi Mi OhMi Mi Oh , Hong Seok ParkHong Seok Park , Du Geon MoonDu Geon Moon , and Sun Tae AhnSun Tae Ahn View All Author Informationhttps://doi.org/10.1097/01.JU.0001008788.18007.3f.16AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Metabolic health and obesity are not stable conditions, however effect of changes in the status of these conditions on urolithiasis remains unclear. In this study, we tried to determine whether changes in metabolic health and obesity affect the incidence of urolithiasis using national health screening cohort. METHODS: The National Health Insurance Service-National Health Screening database was used for this study (NHIS-2022-2-156). The study cohort consisted of 514,866 health screening examinees between 2009 and 2010. Metabolic health was determined according to the modified criteria by the National Cholesterol Education Program-Adult Treatment Panel III, while obesity was determined by body mass index. Based on the results of initial (2009-2010) and second (2011-2012) health screening, the cohorts were divided according to changes in obesity and metabolic health status, after which participants were followed-up for urolithiasis from 2013 to 2020. Cox proportional hazards regression was used to determine adjusted hazard ratios (aHRs) and 95% CIs. This study was approved by Ethical Committee of the Korea University Hospital. RESULTS: Total 265,162 of examinees who contributed a total of 1,814,200 person-years of follow up were eligible for this cohort study, during which 11,641 subjects were developed urolithiasis. Groups with persistent obese and metabolically unhealthy showed highest aHRs, whereas in groups with improved obesity or metabolic health observed lower aHRs compared to persistent groups (Table 3). CONCLUSIONS: We found maintaining metabolically healthy and normal weight or improving metabolic health and reducing weight may lead to decreased risk of urolithiasis development. Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e670 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Won Ku Hwang More articles by this author Hyo Jong Kim More articles by this author Seon Beom Jo More articles by this author Hyun Soo Lee More articles by this author Jong Wook Kim More articles by this author Mi Mi Oh More articles by this author Hong Seok Park More articles by this author Du Geon Moon More articles by this author Sun Tae Ahn More articles by this author Expand All Advertisement PDF downloadLoading ...