Mp40-14 Establishing a Connection Between Birthweight and Nephrolithiasis Among Adult Stone Formers

You have accessJournal of UrologyStone Disease: Epidemiology & Evaluation I (MP40)1 May 2024MP40-14 ESTABLISHING A CONNECTION BETWEEN BIRTHWEIGHT AND NEPHROLITHIASIS AMONG ADULT STONE FORMERS Carla M. Miguel, Michael Leyderman, and Scott Wiener Carla M. MiguelCarla M. Miguel , Michael LeydermanMichael Leyderman , and Scott WienerScott Wiener View All Author Informationhttps://doi.org/10.1097/01.JU.0001008788.18007.3f.14AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Low birthweight is associated with hypercalciuria and stone formation in neonates. No studies have investigated the relationship between birthweight and nephrolithiasis in adulthood. We hypothesize low birthweight correlates with 24-hour urine parameters known to be associated with nephrolithiasis among adult stone formers. METHODS: Stone-forming adults who completed a 24-hour urinalysis in 2003-2022 were given a telephone questionnaire regarding prior stone events, medical, birth, and family history. Birthweight was stratified as low, normal, or high based on American College of Obstetricians and Gynecologists criteria. Using SPSS 26, patients were stratified by birthweight and urinary parameters compared by ANOVA. Multivariate regression adjusted for age, BMI, and remaining 24-hour urinary parameters assessed if birthweight was an independent predictor of parameters identified as significant on univariate analysis (SUNY IRB 1381875). RESULTS: Survey response rate was 228/681 (33.5%), of which 137 (20.1%) patients provided a birth history and were included. 24-hour urine oxalate (23.9±6.7 vs 36.8±20.6, p=0.01) and uric acid (0.50±0.2 vs 0.70±0.2, p=0.02) levels were statistically lower in low birthweight compared to high birthweight patients. 24-hour magnesium levels were significantly lower in normal compared to high birthweight patients (92.1±35.9 vs 118.1±77.7, p=0.047). 24-hour Calcium/creatinine was significantly higher in low birthweight compared to high birthweight patients (220.4±74.6 vs 137.9±65.5, p<0.05). On multiple regressions testing, birthweight remained an independent predictor of 24-hour urine oxalate level (OR, CI, p=0.044). There was no difference in number of stone events or surgeries between birthweight categories. CONCLUSIONS: Low birthweight calcium stone formers had higher Calcium/Creatinine ratios and lower 24-hour urinary oxalate, uric acid, and magnesium levels compared to high birthweight stone formers. Birthweight remained an independent predictor of 24-hour urine oxalate on multivariate regression suggesting underlying differences in renal physiology between low and high birthweight individuals. Prospective studies with higher power are needed to determine if a causal relationship exists between birth weight and kidney stone risk. Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e669 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Carla M. Miguel More articles by this author Michael Leyderman More articles by this author Scott Wiener More articles by this author Expand All Advertisement PDF downloadLoading ...