Pd11-07 Outcomes of Multiple Partial Nephrectomy for Multifocal Renal Masses

You have accessJournal of UrologyKidney Cancer: Localized: Surgical Therapy I (PD11)1 May 2024PD11-07 OUTCOMES OF MULTIPLE PARTIAL NEPHRECTOMY FOR MULTIFOCAL RENAL MASSES Barbara Vieira Lima Aguiar Melao, Nicole Benfante, Natalia Picola Brau, Ines Rivero Belenchon, Claudia Mercader Barrull, Jonathan Coleman, Paul Russo, and Karim Touijer Barbara Vieira Lima Aguiar MelaoBarbara Vieira Lima Aguiar Melao , Nicole BenfanteNicole Benfante , Natalia Picola BrauNatalia Picola Brau , Ines Rivero BelenchonInes Rivero Belenchon , Claudia Mercader BarrullClaudia Mercader Barrull , Jonathan ColemanJonathan Coleman , Paul RussoPaul Russo , and Karim TouijerKarim Touijer View All Author Informationhttps://doi.org/10.1097/01.JU.0001008604.95535.b9.07AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Multiple partial nephrectomy (MPN) during a single operation, although challenging, could be an effective option to radical nephrectomy (RN). The goal of this study is to analyze oncological and functional outcomes of MPN for multifocal renal masses. METHODS: We reviewed data of 393 patients who underwent MPN between 2000 and 2023, from a prospectively maintained database. Time-to-event analysis was performed using the Kaplan-Meier method and all analyses were performed using Stata, version 15.0. RESULTS: 361 (92%) MPN were performed in bilateral and 32 (8%) in solitary kidneys. The most common histologic subtype was clear cell in both groups and majority of the patients had T1a tumors, 66% in the non-solitary and 56% in solitary kidney group. Positive surgical margins were similar: 13% in the solitary group vs. 11% in the non-solitary. Concordant histology between tumors was higher in the solitary group (81%) vs. 46%. We described a total of 93 (23.7%) overall complications; 31% and 28% Clavien-Dindo grade III on solitary and non-solitary, respectively.There were 24 patients who developed metastasis (9 in solitary and 15 in the non-solitary group). The estimates of overall survival at 5 years was 94% (95% CI: 91%, 96%) in the non-solitary group and 70% (95% CI: 49%, 84%) in the solitary group.The preoperative eGFR in the solitary group was 57 ml/min/1,73 m2 (42-74), 42 (24.8-54.6) at 6 months and 42.1 (31.8-65.7) at one year postoperatively. In the non-solitary, the eGFR was 73 ml/min/1,73 m2 (61-90) preoperatively, 66.3 (52.8-81.0) at 6 months and 64.4 (51.2-81.0) at one year postoperatively. CONCLUSIONS: MPN is an appropriate and safe treatment option for multifocal renal masses. Although a decrease of renal function is observed in the first 6 months, MPN provides good preservation long-term and represents a feasible alternative to RN, particularly in the patient population with solitary kidney. However, data highlights how this procedure is technically challenging and is best performed in experienced centers. Download PPT Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e252 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Barbara Vieira Lima Aguiar Melao More articles by this author Nicole Benfante More articles by this author Natalia Picola Brau More articles by this author Ines Rivero Belenchon More articles by this author Claudia Mercader Barrull More articles by this author Jonathan Coleman More articles by this author Paul Russo More articles by this author Karim Touijer More articles by this author Expand All Advertisement PDF downloadLoading ...