The study findings demonstrated a significant association between C-reactive protein levels and trabecular bone score : NHANES 2005-2008

Abstract Objectives: The association between C-reactive protein and bone density has been primarily investigated in previous studies., with little to no research investigating its relationship with total bone trabecular score. Methods: Data from the NHANES database (500 males and 633 females) were utilized in this study to perform a multiple weighted linear regression analysis to estimate this relationship of CRP and TBS. Subsequently, population characterization, univariate logistic regression analysis, subgroup and interaction analysis were in progress. Results: Upon covariate adjustment, the analysis revealed a notable negative correlation between CRP and TBS(β=-0.0081; 95% CI (-0.0142, -0.0019); P=0.009). Furthermore, no interactions were detected within any subgroups. Conclusion: This finding enhances our comprehension of the relationship in inflammation and bone health, offering the novel research outlook for the treatment and prevention of osteoporosis and osteoporotic fractures.