April 15, 2024Open Access

Supplementary Figure S5 from A B7-H4–Targeting Antibody–Drug Conjugate Shows Antitumor Activity in PARPi and Platinum-Resistant Cancers with B7-H4 Expression

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Antitumor activity of the antibody drug conjugate requires target expression, as the agent demonstrates a complete lack of activity across b7 h4 negative cancer cell lines.
In vitro assessment of cell lines resistant to platinum and parp inhibition showed no cytotoxic response to the antibody drug conjugate in the absence of the b7 h4 antigen.
Target-specific action highlights the therapeutic selectivity of the antibody drug conjugate, though findings remain restricted to preclinical cancer cell lines.

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Implication

Preclinical evaluation demonstrates lack of B7-H4-ADC activity in B7-H4 negative cell lines, highlighting antigen-dependent selectivity in resistant cancers.

Abstract

B7-H4-ADC lack of activity in B7-H4 negative cell lines.

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Gitto et al. (2024) studied this question.

synapsesocial.com/papers/68e6f2a2b6db64358766d0f8 https://doi.org/10.1158/1078-0432.25603629

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Implication

Preclinical evaluation demonstrates lack of B7-H4-ADC activity in B7-H4 negative cell lines, highlighting antigen-dependent selectivity in resistant cancers.

Abstract

B7-H4-ADC lack of activity in B7-H4 negative cell lines.

Supplementary Figure S5 from A B7-H4–Targeting Antibody–Drug Conjugate Shows Antitumor Activity in PARPi and Platinum-Resistant Cancers with B7-H4 Expression

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Implication

Abstract

Discussion

Cite This Study

Supplementary Figure S5 from A B7-H4–Targeting Antibody–Drug Conjugate Shows Antitumor Activity in PARPi and Platinum-Resistant Cancers with B7-H4 Expression

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

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