Pd25-07 Time Course of Repeat Fulgurations for the Treatment of Interstitial Cystitis/Painful Bladder Syndrome With Hunner Lesions

You have accessJournal of UrologyInfections/Inflammation/Cystic Disease of the Genitourinary Tract: Interstitial Cystitis (PD25)1 May 2024PD25-07 TIME COURSE OF REPEAT FULGURATIONS FOR THE TREATMENT OF INTERSTITIAL CYSTITIS/PAINFUL BLADDER SYNDROME WITH HUNNER LESIONS Julian Frankel, Dan Kent, Lara Maclachlan, Arthur Mourtzinos, and Joshua Hayden Julian FrankelJulian Frankel , Dan KentDan Kent , Lara MaclachlanLara Maclachlan , Arthur MourtzinosArthur Mourtzinos , and Joshua HaydenJoshua Hayden View All Author Informationhttps://doi.org/10.1097/01.JU.0001008584.88541.ff.07AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Current evidence seems to suggest that interstitial cystitis/painful bladder syndrome (IC/PBS) can be divided phenotypically into those with Hunner lesions and those without. Hunner lesion phenotype is treated with fulguration. Presently there is an incomplete understanding of the duration of the response to fulguration as well as the natural progression of the disease. We aim to characterize the time course of repeated fulgurations. METHODS: A retrospective chart review on all patients who underwent a fulguration for IC/PBS with Hunner lesions between 2015 and 2023 within an academic health system was conducted. Time to event analysis was used to assess the number of fulgurations per patient, time between fulgurations, and progression to cystectomy. Patient's time at risk was defined from first fulguration to cystectomy or last known follow up. RESULTS: 94 total procedures were performed on 40 patients. The mean age of the cohort was 69.3 years, and 87.5% were women. Mean follow up time was 30 months. 27/40 (67.5%) received 1 repeat fulguration, 16/40 (40%) received 2, and 6/40 (15%) received 3+. At 12 months, 45% of patients required a second fulguration, rising to 62.5% after 24 months, and remaining stable at 64.3% at 36 months and 72 % at 48 months. Out of the 27 patients total who required a repeat fulguration, 18/27 (66%) received one within 12 months and 25/27 (93%) received one within 24 months. Of the 6 patients that progressed to cystectomy, the mean number of prior fulgurations was 2.5 and the mean time between initial fulguration and cystectomy was 24.1 months. CONCLUSIONS: IC/PBS patients with Hunner lesions can be effectively treated with fulguration, however a majority of Hunner ulcer phenotype IC/BPS will require repeat fulguration within 2 years and may benefit from close followup. A small percentage will progress to cystectomy. Download PPT Source of Funding: N/A © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e538 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Julian Frankel More articles by this author Dan Kent More articles by this author Lara Maclachlan More articles by this author Arthur Mourtzinos More articles by this author Joshua Hayden More articles by this author Expand All Advertisement PDF downloadLoading ...