Mp13-11 a Preconception Cohort Study of Nicotine Vaping and Incidence of Spontaneous Abortion

You have accessJournal of UrologyInfertility: Epidemiology & Evaluation I (MP13)1 May 2024MP13-11 A PRECONCEPTION COHORT STUDY OF NICOTINE VAPING AND INCIDENCE OF SPONTANEOUS ABORTION Michael Scott, Chiyuan A. Zhang, Tamran Wang, Alyssa F. Harlow, Ken Rothman, Michael Eisenberg, and Lauren Wise Michael ScottMichael Scott , Chiyuan A. ZhangChiyuan A. Zhang , Tamran WangTamran Wang , Alyssa F. HarlowAlyssa F. Harlow , Ken RothmanKen Rothman , Michael EisenbergMichael Eisenberg , and Lauren WiseLauren Wise View All Author Informationhttps://doi.org/10.1097/01.JU.0001008832.14212.d6.11AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Tobacco smoking in either partner has been associated with an increased risk of spontaneous abortion (SAB) in prior studies. Nicotine vaping has increased in prevalence in recent years in part due to its perception as a safer alternative to smoking. However, there are limited data on the impact of vaping on reproductive health. This study evaluated the association between vaping in both partners and SAB. METHODS: We analyzed data from participants in the Pregnancy Study Online (PRESTO), a preconception cohort study of North American couples planning pregnancy (2013-2023). Female participants and their male partners completed baseline questionnaires in the preconception period and reported information about demographics and lifestyle characteristics, including nicotine vaping and other tobacco use. Female participants completed bimonthly follow-up questionnaires for up to 12 months to update their pregnancy status. We analyzed data on 6,136 female participants and 1,668 couples where both partners provided complete data on vaping. We used Cox proportional hazards regression models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between vaping and SAB incidence, adjusting for demographic and lifestyle factors. RESULTS: Mean age was 32 years for males and 30 years for females with 85% identifying as white. In the full cohort, 13% of females reported current vaping, 3% current cigarette smoking, and 11% former smoking at baseline. In the couple-based cohort, 19% of males reported current vaping at baseline. SAB occurred in 22% of pregnancies in the full cohort (n=6,136 females) and 24% of pregnancies in the couple-based cohort (n=1,668 couples). In the couple-based cohort, there was a nearly null association between current male vaping and SAB incidence (HR 0.95, 95% CI 0.72-1.26), and a modest but imprecise positive association between female vaping (HR 1.31, 95% CI 0.61-2.79) and SAB incidence. In the full cohort, relative to no female tobacco use, HRs were 1.03 for female vaping only (95% CI 0.82-1.29), 0.97 for female smoking only (95% CI 0.81-1.16), and 0.92 for female vaping and smoking (95% CI 0.73-1.16). Additional analysis of female participants after stratifying by finer categories of smoking status (current, former, or never) did not identify any meaningful association with SAB incidence. CONCLUSIONS: Nicotine vaping in either partner during the preconception period was not appreciably associated with SAB incidence. There was also little evidence that cigarette smoking modified the association between vaping and SAB incidence. Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e214 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Michael Scott More articles by this author Chiyuan A. Zhang More articles by this author Tamran Wang More articles by this author Alyssa F. Harlow More articles by this author Ken Rothman More articles by this author Michael Eisenberg More articles by this author Lauren Wise More articles by this author Expand All Advertisement PDF downloadLoading ...