Mp13-12 a Preconception Cohort Study of Alcohol Use and Incidence of Spontaneous Abortion

You have accessJournal of UrologyInfertility: Epidemiology & Evaluation I (MP13)1 May 2024MP13-12 A PRECONCEPTION COHORT STUDY OF ALCOHOL USE AND INCIDENCE OF SPONTANEOUS ABORTION Michael Scott, Chiyuan A. Zhang, Michael Eisenberg, and Lauren Wise Michael ScottMichael Scott , Chiyuan A. ZhangChiyuan A. Zhang , Michael EisenbergMichael Eisenberg , and Lauren WiseLauren Wise View All Author Informationhttps://doi.org/10.1097/01.JU.0001008832.14212.d6.12AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: High alcohol consumption may adversely affect fetal health. However, minimal data exists regarding its impact on pregnancy loss. This study evaluated associated between preconception male and female alcohol consumption and spontaneous abortion (SAB). METHODS: We analyzed data from participants in the Pregnancy Study Online (PRESTO), a preconception cohort study of North American couples planning a pregnancy (2013-2023). Female participants and their male partners completed baseline questionnaires in the preconception period and reported information about demographics and lifestyle characteristics, including alcohol consumption. Female participants then completed bimonthly follow-up questionnaires for 12 months to update their pregnancy status. We analyzed data on 9,414 female participants and 2,613 couples where both partners provided complete data on alcohol consumption. Current alcohol consumption was categorized as none, light (0.1-6.9 drinks/week), moderate (7.0-13.9 drinks/week), and heavy (≥14.0 drinks/week). We used Cox proportional hazards regression models to estimate hazard ratios (HRs) and 95% confidence intervals (CI) for the association between current alcohol consumption and SAB, adjusting for demographic and lifestyle factors. RESULTS: Mean age was 32 years for males and 30 years for females with 86% identifying as white. In the full cohort, 60% of females reported light drinking, 11% moderate drinking, and 3% heavy drinking. In the couple-based cohort, 49% of males reported light drinking, 20% moderate drinking, and 12% heavy drinking. SAB occurred in 22% of pregnancies in the couple-based cohort and 21% of pregnancies in the full cohort. In the couple-based cohort, there was no meaningful association between male partner light drinking (HR 0.98, 95% CI 0.77-1.25), moderate drinking (HR 0.95, 95% CI 0.70-1.28), or heavy drinking (HR 0.94, 95% CI 0.67-1.31) compared with no drinking. Compared to non-drinking females, moderate (HR 0.97, 95% CI 0.83-1.13) and heavy (HR 0.86, HR 0.64-1.15) drinking was not appreciably associated with SAB in the full cohort. In contrast, light drinking (HR 0.88, 95% CI 0.79-0.98) was associated with slightly lower SAB risk for females. Further stratification by female partner age did not show meaningful evidence of effect modification on the association between alcohol consumption and SAB in the couple-based cohort. CONCLUSIONS: Preconception alcohol consumption by either partner was not meaningfully associated with incidence of SAB. Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e215 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Michael Scott More articles by this author Chiyuan A. Zhang More articles by this author Michael Eisenberg More articles by this author Lauren Wise More articles by this author Expand All Advertisement PDF downloadLoading ...