Pd11-11 Association Between Oral Antithrombotic Drugs Use and Bleeding in Partial Nephrectomy: A Retrospective Cohort Study

You have accessJournal of UrologyKidney Cancer: Localized: Surgical Therapy I (PD11)1 May 2024PD11-11 ASSOCIATION BETWEEN ORAL ANTITHROMBOTIC DRUGS USE AND BLEEDING IN PARTIAL NEPHRECTOMY: A RETROSPECTIVE COHORT STUDY Yuzhe Tang, Gang Zhang, Jianxing Li, and Steven Lee Chang Yuzhe TangYuzhe Tang , Gang ZhangGang Zhang , Jianxing LiJianxing Li , and Steven Lee ChangSteven Lee Chang View All Author Informationhttps://doi.org/10.1097/01.JU.0001008604.95535.b9.11AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: It is a commonly held belief that antithrombotic drugs will increase bleeding especially increase operation bleeding risk. Partial nephrectomy (PN) is a high-risk bleeding operation. Although whether perioperative period oral antiplatelet (AP) and anticoagulant (AC) drugs use can lead to bleeding in PN is controversial, in some cases, we do not have the choice to stop the AP/AC drugs. Therefore, this study analyzes the association between oral AP/AC use and bleeding complications in partial nephrectomy in a large cohort. METHODS: Using the Premier Hospital Database, we performed a retrospective cohort study of patients undergoing partial nephrectomy to manage kidney cancer and renal masses from 2003 to 2020. The study cohort was limited to adult patients undergoing elective surgery. Using administrative codes and billing, we assessed for an association between AP/AC drug use and bleeding complication using mixed-effects multiple logistic regression models controlling for a wide range of clinical-demographic, surgical, and hospital factors. The primary outcome was bleeding within 90 days after surgery. Secondary outcomes were mortality rate 90 days after surgery and length of hospital stay. RESULTS: The study cohort comprised of 41,277 patients undergoing partial nephrectomy, of which 10.9% had bleeding complications. Mixed-effects multivariable logistic regression models revealed that compared to non-users, AP was associated with modest increased odds for bleeding (OR 1.28; 95% CI: 1.12-1.46; p<0.01) and AC was associated with very significant increased odds for bleeding (OR 2.19; 95% CI: 1.79-2.69; p<0.01), and the AP and AC combination group was associated with the highest bleeding risk (OR 3.08; 95% CI: 2.06-4.59; p<0.01). CONCLUSIONS: AC/AP use is associated with a significant increase in bleeding complications following partial nephrectomy surgery, compared with AP, AC induces more probability of bleeding; AP and AC combination lead to even more bleeding risk. Download PPT Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e254 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Yuzhe Tang More articles by this author Gang Zhang More articles by this author Jianxing Li More articles by this author Steven Lee Chang More articles by this author Expand All Advertisement PDF downloadLoading ...