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This is a Cross-Sectional Study study.

October 8, 2025CureusOpen Access

Assessment of Serum Calcium, Total Alkaline Phosphatase, Vitamin D Levels, and Quality of Life in Patients on Prolonged Antiepileptic Therapy: A Cross-Sectional Study

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Reduced bone mineral density was more prevalent in patients on polytherapy compared to monotherapy, affecting overall health.
Significant differences in serum calcium, vitamin D, and alkaline phosphatase levels were observed between treatment groups.
Factors like obesity, alcohol use, and vitamin D deficiency are crucial predictors of low bone density in patients receiving antiepileptic drugs.
Regular biochemical monitoring and lifestyle changes are recommended to improve patient outcomes and minimize adverse effects.

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Cross-sectional study found lower bone mineral density and quality of life in patients on polytherapy, suggesting monitoring is vital.

Nallaperumal et al. (2025) studied this question.

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