What type of study is this?

This is a Experimental Study study.

October 8, 2025BiomoleculesOpen Access

Glucocorticoids Induce an Opposite Metabolic Switch in Human Monocytes Contingent upon Their Polarization

View Full Paper

Ask AI

Bookmark

Dexamethasone treatment can reverse metabolic processes in monocytes activated by LPS, shifting them toward oxidative phosphorylation.
Monocytes activated by IL-4 and IL-13 primarily favor oxidative phosphorylation, which is suppressed by glucocorticoid treatment.
Human monocytes display distinct metabolic responses that vary with different activating stimuli and conditions of glucocorticoid exposure.
These findings highlight the specific regulation of monocyte energy metabolism and potential relevance for inflammatory responses.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

This research reveals how glucocorticoids regulate metabolism in monocytes depending on their polarization, suggesting implications for inflammation and homeostasis.

Cite This Study

Peruzzi et al. (2025) studied this question.

synapsesocial.com/papers/68e6f342f8145af55aeacbdf https://doi.org/10.3390/biom15101422

View Full Paper

Ask AI

Bookmark

Implication

This research reveals how glucocorticoids regulate metabolism in monocytes depending on their polarization, suggesting implications for inflammation and homeostasis.

Glucocorticoids Induce an Opposite Metabolic Switch in Human Monocytes Contingent upon Their Polarization

Key Points

Discussion

Implication

Cite This Study

Glucocorticoids Induce an Opposite Metabolic Switch in Human Monocytes Contingent upon Their Polarization

Key Points

Discussion

Implication

Cite This Study

Also Consider

Also Consider