Correlation of Clinicopathological Profile With Receptor Status in Breast Carcinoma: An Observational Study in a Tertiary Care Hospital

Introduction: Breast cancer is the most prevalent cancer worldwide in females and a primary cause of mortality. It is a systemic disease with diverse biological subtypes, clinical presentation, pathological types, and molecular features that impact prognosis and outcome. The molecular organization of breast cancer is a better predictor for diagnosis and treatment. The study aimed to analyze the clinicopathological characterization and correlation of breast tumors with progesterone (PR), estrogen (ER), and human epidermal receptor protein-2/neu status (HER-2/neu). Material and Methods: After approval from the IEC, this prospective study was conducted on 100 patients diagnosed with breast carcinoma. The expression patterns of PR, ER and HER-2/NEU were studied. Clinical features, pathologic features such as age of the patient, tumour size, grade, and lymph node status and their correlation with receptors were compared. Relevant statistical analysis was done. Results: Of the 100 patients, ER positivity was seen in 42% cases, PR positivity in 32% and HER2/neu (3+) in 30% cases. Majority of grade I tumors were ER and PR positive and majority of grade III tumors were triple negative. Triple negative prole was seen in secretory carcinoma. ER, PR and HER2 status was not signicantly associated with age of the patients and tumour size. The immunohistochemical types ER/PR +ve Her2neu +ve and ER/PR -ve Her2neu -ve are signicantly related to grading of tumours. Conclusions: From the results, it was concluded that ER, PR and HER-2 status correlates well with histopathological grading. These results highlight the fact that molecular subtypes correlate with diagnosis and aid in targeted therapy