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April 12, 2024British Journal of Pharmacology

Differential contributions of G protein‐ or arrestin subtype‐mediated signalling underlie urocortin 3‐induced somatostatin secretion in pancreatic δ cells

Kaiyu Wang Ming‐Xin Gao Haibo Qi Wentao An Jing‐Yu Lin Shanglei Ning Fan Yang Peng Xiao Jie Cheng Wei Pan Qiu‐xia Cheng Jin Wang Le Fang Jin‐Peng Sun Xiao Yu

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Abstract

Pancreatic islets are modulated by cross-talk among different cell types and paracrine signalling plays important roles in maintaining glucose homeostasis. Urocortin 3 (UCN3) secreted by pancreatic β cells activates the CRF

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Cite This Study

Wang et al. (2024) studied this question.

synapsesocial.com/papers/68e6f609b6db643587670bc3 https://doi.org/10.1111/bph.16351

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Urocortin III Is Expressed in Pancreatic β-Cells and Stimulates Insulin and Glucagon SecretionOriginal Research · 2003 · 127 citations
2Locally released somatostatin triggers cAMP and Ca2+ signaling in primary cilia to modulate pancreatic β-cell function2024 · 1 citations
3Protective effects of urocortin 2 against caerulein-induced acute pancreatitisOriginal Research · 2019 · 7 citations
4Somatostatin receptors shape insulin and glucagon output within the pancreatic islet in mice through direct and paracrine effectsOriginal Research · 2026
5Commentary on “Intra‐islet α‐cell Gs signaling promotes glucagon release”2024