Mechanistic view of folic acid on oral ulcers and oral cancers

• Supplementation with folic acid has been shown to reduce the occurrence, severity, and duration of oral ulcers, providing potential relief for individuals affected by this condition. • Folic acid's advantages extend beyond just managing oral ulcers; it holds potential in addressing various oral health issues such as periodontal diseases by promoting the healing of tissues and diminishing inflammation. • Folic acid affects both oral ulcers and oral cancers through various mechanisms, including facilitating DNA synthesis and repair, participating in methylation reactions, acting as an antioxidant, supporting immune function, and influencing the expression of folate receptors. • Deficiency in folic acid is associated with cardiovascular disease and specific types of cancer, suggesting that supplementation not only enhances oral health but also lowers the risk of serious health problems linked with deficiency.