The Comparison of Physicochemical Properties of Chitosan/Silk Fibroin/Collagen-Based Materials Cross-Linked with Chemical Agents

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first_page Download PDF settings Order Article Reprints Font Type: Arial Georgia Verdana Font Size: Aa Aa Aa Line Spacing:    Column Width:    Background: Open AccessAbstract The Comparison of Physicochemical Properties of Chitosan/Silk Fibroin/Collagen-Based Materials Cross-Linked with Chemical Agents † by Sylwia Grabska-ZielińskaSylwia Grabska-Zielińska SciProfiles Scilit Preprints.org Google Scholar 1,* and Alina SionkowskaAlina Sionkowska SciProfiles Scilit Preprints.org Google Scholar 2 1 Faculty of Chemical Technology and Engineering, Bydgoszcz University of Science and Technology, Seminaryjna 3, 85-326 Bydgoszcz, Poland 2 Faculty of Chemistry, Nicolaus Copernicus University in Toruń, Gagarin 7, 87-100 Torun, Poland * Author to whom correspondence should be addressed. † Presented at the 3rd International Electronic Conference on Biomolecules, 23–25 April 2024; Available online: https://sciforum.net/event/IECBM2024. Proceedings 2024, 103(1), 14; https://doi.org/10.3390/proceedings2024103014 Published: 12 April 2024 Download keyboard_arrow_down Download PDF Download PDF with Cover Download XML Download Epub Versions Notes Keywords: silk fibroin; chitosan; collagen; cross-linking; biopolymers Interest in biomaterials based on natural polymers has recently surged. The natural polymers are large molecular compounds, which can be obtained from living organisms or are produced by living organisms. Biopolymers typically exhibit properties highly desirable in tissue engineering, including biocompatibility, biodegradability, and minimal immune responses upon introduction into the human body. Chitosan, collagen, and silk fibroin are biopolymers commonly used in tissue engineering to obtain three-dimensional scaffolds [1]. They can be utilized as fillings for repairing small bone defects. However, materials obtained only from biopolymers or their mixtures may have insufficiently physicochemical properties. Therefore, there is a need to cross-link such materials [1]. The purpose of this work was to obtain and characterize 3D scaffolds based on chitosan, collagen, and silk fibroin modified with various cross-linking agents [2,3,4]. Collagen was obtained from young rat tail tendons, and silk fibroin was obtained from Bombyx mori cocoons. Materials were obtained using the lyophilization method, and their physicochemical properties, such as porosity, density, moisture content, and mechanical strength, were evaluated. Dialdehyde chitosan, dialdehyde starch, and glyoxal were used as modifiers of the three-component materials. Based on the results, it can be concluded that the properties of biopolymer materials depend on their weight ratio composition and the cross-linking agent. The study revealed that cross-linked materials exhibited a high swelling rate and sufficient porosity, rendering them suitable for tissue engineering applications. Mechanical properties vary depending on the composition of the blends. Novel biopolymeric composites based on collagen, chitosan, and silk fibroin, chemically cross-linked, hold potential for various biomedical applications, particularly in bone tissue regeneration. Author ContributionsConceptualization, S.G.-Z. and A.S.; methodology, S.G.-Z. and A.S.; software, S.G.-Z.; validation, S.G.-Z.; formal analysis, S.G.-Z.; investigation, S.G.-Z.; resources, S.G.-Z. and A.S.; data curation, S.G.-Z.; writing—original draft preparation, S.G.-Z.; writing—review and editing, S.G.-Z. and A.S.; visualization, S.G.-Z.; supervision, A.S.; project administration, S.G.-Z.; funding acquisition, S.G.-Z. All authors have read and agreed to the published version of the manuscript.FundingThis research was founded by National Science Centre, grant 2018/31/N/ST8/01391 and by Polish National Agency for Academic Exchange, Iwanowska project PPN/IWA/2018/1/00064/U/00001.Institutional Review Board StatementNot applicable.Informed Consent StatementNot applicable.Data Availability StatementThe data presented in this study are available on request from the corresponding author.Conflicts of InterestThe authors declare no conflicts of interest.ReferencesGrabska-Zielińska, S.; Sionkowska, A. How to Improve Physico-Chemical Properties of Silk Fibroin Materials for Biomedical Applications?—Blending and Cross-Linking of Silk Fibroin—A Review. Materials 2021, 14, 1510. [Google Scholar] [CrossRef] [PubMed]Grabska-Zielińska, S.; Sionkowska, A.; Olewnik-Kruszkowska, E.; Reczyńska, K.; Pamuła, E. Is Dialdehyde Chitosan a Good Substance to Modify Physicochemical Properties of Biopolymeric Materials? Int. J. Mol. Sci. 2021, 22, 3391. [Google Scholar] [CrossRef] [PubMed]Grabska-Zielińska, S.; Sionkowska, A.; Coelho, C.C.; Monteiro, F.J. Silk Fibroin/Collagen/Chitosan Scaffolds Cross-Linked by a Glyoxal Solution as Biomaterials toward Bone Tissue Regeneration. Materials 2020, 13, 3433. [Google Scholar] [CrossRef] [PubMed]Grabska-Zielińska, S.; Sionkowsa, A.; Reczyńska, K.; Pamuła, E. Physico-Chemical Characterization and Biological Tests of Collagen/Silk Fibroin/Chitosan Scaffolds Cross-Linked by Dialdehyde Starch. Polymers 2020, 12, 372. [Google Scholar] [CrossRef] [PubMed]Disclaimer/Publisher's Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content. © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Share and Cite MDPI and ACS Style Grabska-Zielińska, S.; Sionkowska, A. The Comparison of Physicochemical Properties of Chitosan/Silk Fibroin/Collagen-Based Materials Cross-Linked with Chemical Agents. Proceedings 2024, 103, 14. https://doi.org/10.3390/proceedings2024103014 AMA Style Grabska-Zielińska S, Sionkowska A. The Comparison of Physicochemical Properties of Chitosan/Silk Fibroin/Collagen-Based Materials Cross-Linked with Chemical Agents. Proceedings. 2024; 103(1):14. https://doi.org/10.3390/proceedings2024103014 Chicago/Turabian Style Grabska-Zielińska, Sylwia, and Alina Sionkowska. 2024. 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