Complex CAD with No Cardiac Risk Factors Revealing a Werner Syndrome Diagnosis in 52 Year Old Moroccan Male, (An Original Case report of Cardiology Department at Casablanca University Hospital, Morocco)

Werner syndrome (WS), also called premature aging, is a very rare genetic disorder with autosomal recessive inheritance, which is characterized not only by premature aging but also by an increased risk of cardiovascular diseases and cancer (8).This case report talks about a 52-year-old man, with angina pectoris episodes exertion-induced and with stress test findings positive, who was diagnosed with CAD in non-diabetic, non-smoking status with conventional cardiovascular risk factors rare.The subsequent diagnostic studies including TTE and coronary angiography revealed very severe, multivessel disease.The complete genetic study proved that the diagnosis of Werner's Syndrome was true, through the search for a homozygous mutation in the WRN gene ( 9).The patient treatment scheme involves medical treatment for ischemic heart disease as well as coronary artery bypass grafting referral.This study emphasizes the crucial need to think about the WS in patients having atypical CAD symptoms and thus realizing the importance of awareness among the clinical staff to detect clues that point to WS for quick diagnosis and management.