Genetic study reveals altered transcriptional programs and glial neuronal signaling in Drosophila, highlighting pathways of neuronal toxicity in frontotemporal dementia.
Missense mutations in the gene encoding the microtubule-associated protein TAU (current and approved symbol is MAPT) cause autosomal dominant forms of frontotemporal dementia. Multiple models of frontotemporal dementia based on transgenic expression of human
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Bukhari et al. (2024) studied this question.
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